State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou, 310027, China.
Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, China.
Nat Commun. 2024 Oct 17;15(1):8972. doi: 10.1038/s41467-024-53302-5.
Neurogenic bladder often occurs after pelvic ganglia injury. Its symptoms, like severe urinary retention and incontinence, have a significant impact on individuals' quality of life. Unfortunately, there are currently no effective treatments available for this type of injury. Here, we designed a fiber-enhanced tissue bandage for injured pelvic ganglia. Tight junctions formed in tissue bandages create a mini tissue structure that enhances resistance in an in vivo environment and delivers growth factors to support the healing of ganglia. Strength fibers are similar to clinical bandages and guarantee ease of handling. Furthermore, tissue bandages can be stored at low temperatures over 5 months without compromising cell viability, meeting the requirements for clinical products. A tissue bandage was applied to a male rat with a bilateral major pelvic ganglia crush injury. Compared to the severe neurogenic bladder symptoms observed in the injury and scaffold groups, tissue bandages significantly improved bladder function. We found that tissue bandage increases resistance to mechanical injury by boosting the expression of cytoskeletal proteins within the major pelvic ganglia. Overall, tissue bandages show promise as a practical therapeutic approach for ganglia repair, offering hope for developing more effective treatments for this thorny condition.
神经原性膀胱常发生于盆神经节损伤后。其严重的尿潴留和失禁等症状，对个体的生活质量有显著影响。然而，目前针对这种损伤尚无有效的治疗方法。在这里，我们设计了一种用于损伤盆神经节的纤维增强组织绷带。组织绷带上形成的紧密连接形成了一个微型组织结构，增强了体内环境的阻力，并输送生长因子来支持神经节的愈合。强度纤维类似于临床绷带，保证了易于处理。此外，组织绷带可以在低温下储存超过 5 个月而不影响细胞活力，满足临床产品的要求。将组织绷带应用于双侧主要盆神经节挤压损伤的雄性大鼠。与损伤和支架组观察到的严重神经原性膀胱症状相比，组织绷带显著改善了膀胱功能。我们发现组织绷带通过增加主要盆神经节内细胞骨架蛋白的表达来提高对机械损伤的抵抗力。总的来说，组织绷带作为一种实用的神经节修复治疗方法具有广阔的应用前景，为开发针对这一棘手病症的更有效的治疗方法带来了希望。
