Ishii Orthopaedic and Rehabilitation Clinic, 1089, Shimo-Oshi, Gyoda, Saitama, 361-0037, Japan.
School of Plastic Surgery, Kanazawa Medical University, 1-1 Daigaku Uchinada, Ishikawa, 920-0253, Japan.
J Orthop Surg Res. 2024 Oct 18;19(1):670. doi: 10.1186/s13018-024-05166-0.
Patients with hypoalbuminemia, (serum albumin (SA) < 3.5 g/dL) are at greater risk for complications after surgery, including increased postoperative infection rates after total knee arthroplasty (TKA). This study aimed to analyze both preoperative and postoperative SA in patients who experienced acute periprosthetic infection within the first 4 weeks after surgery.
We retrospectively analyzed data from 490 consecutive TKAs (314 patients). Five patients developed early acute infection requiring surgical treatment. SA data were collected preoperatively (SA) and 1 week postoperatively (SA) to evaluate SA dynamics. Multiple patient and operative parameters that could influence SA were also analyzed.
No statistical differences were found in parameters expected to influence SA values between the surgically treated (STG) and non-treated groups (non-STG). None of the patients in STG had SA and SA below 3.5 g/dL. However, the amount and rate of SA reduction before and after surgery were significantly greater in STG than in non-STG.
SA dynamics revealed a greater reduction in both the amount and rate in STG before and after surgery than in non-STG. No correlation was found between early acute periprosthetic infection after TKA and each SA and SA time point. Further evaluation of the SA value of 3.5 g/dL as a threshold for acute early acute infection is warranted.
血清白蛋白（SA）<3.5g/dL 的低白蛋白血症患者在手术后发生并发症的风险更高，包括全膝关节置换术后（TKA）感染率增加。本研究旨在分析术后 4 周内发生急性假体周围感染的患者的术前和术后 SA。
我们回顾性分析了 490 例连续 TKA（314 例患者）的数据。5 例患者发生早期急性感染，需要手术治疗。收集术前（SA）和术后 1 周（SA）的 SA 数据，以评估 SA 动态。还分析了可能影响 SA 的多个患者和手术参数。
在预期影响 SA 值的参数方面，手术治疗组（STG）和非治疗组（非 STG）之间没有统计学差异。STG 中没有患者的 SA 和 SA 低于 3.5g/dL。然而，STG 术前和术后 SA 减少的数量和速度明显大于非 STG。
SA 动态显示，STG 术前和术后 SA 减少的数量和速度均大于非 STG。TKA 后早期急性假体周围感染与每个 SA 和 SA 时间点之间没有相关性。进一步评估 3.5g/dL 的 SA 值作为急性早期感染的阈值是必要的。
