Borde Neha D, Thesiya Yash M, Mahajan Meera S, Bhale Chandrashekhar P
Department of Pathology, MGM Medical College and Hospital, Aurangabad, Maharashtra, India.
Indian J Pathol Microbiol. 2024 Oct 17. doi: 10.4103/ijpm.ijpm_920_23.
Breast cancer is the most common malignancy among women. Established prognostic markers in breast carcinomas include tumor size, histologic grade, nodal status, lymphovascular invasion, perineural invasion, hormone receptor status, HER-2 status, and age.
To correlate peripheral tumor budding (pTB) with stromal tumor-infiltrating lymphocytes (sTILs) and established prognostic factors in invasive breast carcinoma.
It is a retrospective study conducted at multiple centers including a tertiary care center.
100 cases were included over a period of 2.5 years. All cases of invasive breast carcinoma (IBC) in which excision specimens with lymph node dissection were available were studied. Slides were reviewed for pTB and sTILs. Tumor budding of ≤20/10 hpf was considered low tumor budding, and >20 buds/10 hpf was considered high tumor budding. Tumor budding was correlated with age, tumor size, lymphovascular invasion, perineural invasion, tumor stage (pT, pN), stromal tumor-infiltrating lymphocytes, tumor grade, ductal carcinoma in situ, hormonal receptors, and HER2neu.
Fisher exact test and Chi-square test were used.
We found that high tumor budding was seen in 34 cases and low tumor budding in 66 cases. There was a statistically significant association between high tumor budding and tumor size (P = 0.007), lymphovascular invasion (P < 0.001), perineural invasion (P = 0.004), tumor staging/pT (P = 0.006), nodal staging/pN (P = 0.001), and low sTILs (P < 0.001). However, the association of high tumor budding with parameters like age (P = 0.979), histological type (P = 0.243), tumor grade (P = 0.052), DCIS (P = 0.478), and ER (P = 0.633), and PR (P = 0.544), HER2Neu status (P = 0.171) was not significant.
This study suggests tumor budding score can be used as a prognostic indicator for breast cancer.
乳腺癌是女性中最常见的恶性肿瘤。乳腺癌已确立的预后标志物包括肿瘤大小、组织学分级、淋巴结状态、淋巴管浸润、神经周围浸润、激素受体状态、HER-2状态和年龄。
探讨外周肿瘤芽生（pTB）与基质肿瘤浸润淋巴细胞（sTILs）以及浸润性乳腺癌中已确立的预后因素之间的相关性。
这是一项在包括三级医疗中心在内的多个中心进行的回顾性研究。
在2.5年的时间里纳入了100例病例。对所有有淋巴结清扫切除标本的浸润性乳腺癌（IBC）病例进行研究。对切片进行pTB和sTILs评估。肿瘤芽生≤20/10高倍视野（hpf）被认为是低肿瘤芽生，>20个芽/10 hpf被认为是高肿瘤芽生。肿瘤芽生与年龄、肿瘤大小、淋巴管浸润、神经周围浸润、肿瘤分期（pT、pN）、基质肿瘤浸润淋巴细胞、肿瘤分级、导管原位癌、激素受体和HER2neu进行相关性分析。
采用Fisher精确检验和卡方检验。
我们发现34例为高肿瘤芽生，66例为低肿瘤芽生。高肿瘤芽生与肿瘤大小（P = 0.007）、淋巴管浸润（P < 0.001）、神经周围浸润（P = 0.004）、肿瘤分期/pT（P = 0.006）、淋巴结分期/pN（P = 0.001）以及低sTILs（P < 0.001）之间存在统计学上的显著关联。然而，高肿瘤芽生与年龄（P = 0.979）、组织学类型（P = 0.243）、肿瘤分级（P = 0.052）、导管原位癌（P = 0.478）、雌激素受体（P = 0.633）、孕激素受体（P = 0.544）、HER2Neu状态（P = 0.171）等参数之间的关联不显著。
本研究表明肿瘤芽生评分可作为乳腺癌的预后指标。
