Satpathy Abhishek S, Patnaik Bhabani, Mohapatra Kailash Chandra
Surgery, SCB Medical College and Hospital, Cuttack, IND.
Microbiology, SCB Medical College and Hospital, Cuttack, IND.
Cureus. 2024 Oct 17;16(10):e71705. doi: 10.7759/cureus.71705. eCollection 2024 Oct.
Diabetic foot ulcers (DFUs) are a major cause of morbidity and mortality in people with diabetes mellitus. DFUs are the leading cause of hospitalisation for diabetic patients worldwide, especially in developing countries such as India. This study presents the microbiology profile of DFUs in a tertiary care hospital in the eastern part of India.
We conducted a prospective observational study for 150 DFU patients over a period of two years. We took samples from the DFUs of these patients, cultured them, and tested their antimicrobial susceptibility.
Most diabetic foot infections (DFIs) in our study patients were caused by Gram-negative bacteria, mainly () (19.3%), (14%), and () (12%). The majority of Gram-positive bacteria were susceptible to linezolid, followed by vancomycin and amoxycillin, while the majority of Gram-negative bacteria were susceptible to imipenem and meropenem, followed by ampicillin with sulbactam, amikacin, gentamicin, and ciprofloxacin. Our study revealed that 88.3% of the isolates were monomicrobial.
These findings demonstrated the importance of a local antibiogram, a microbiological exam, and antimicrobial susceptibility testing before starting antibiotic treatment for infections caused by DFUs. This protocol is different from the recommended guidelines for using empirical antibiotics.
糖尿病足溃疡（DFU）是糖尿病患者发病和死亡的主要原因。DFU是全球糖尿病患者住院的主要原因，在印度等发展中国家尤为如此。本研究展示了印度东部一家三级护理医院中DFU的微生物学特征。
我们对150例DFU患者进行了为期两年的前瞻性观察研究。我们从这些患者的DFU中取样，进行培养，并测试其抗菌药敏性。
我们研究中的大多数糖尿病足感染（DFI）由革兰氏阴性菌引起，主要是（此处原文括号内内容缺失）（19.3%）、（此处原文括号内内容缺失）（14%）和（此处原文括号内内容缺失）（12%）。大多数革兰氏阳性菌对利奈唑胺敏感，其次是万古霉素和阿莫西林，而大多数革兰氏阴性菌对亚胺培南和美罗培南敏感，其次是氨苄西林舒巴坦、阿米卡星、庆大霉素和环丙沙星。我们的研究表明，88.3%的分离株为单一微生物。
这些发现表明，在开始针对DFU引起的感染进行抗生素治疗之前，进行局部抗菌谱分析、微生物学检查和抗菌药敏试验非常重要。该方案与使用经验性抗生素的推荐指南不同。
