Singson Sangthang, Shastry Shamee, Sudheesh N, Chawla Kiran, Madiyal Mridula, Kandasamy Dhivya, Mukhopadhyay Chiranjay
Department of Immunohematology and Blood Transfusion, Kasturba Medical College, Manipal. Manipal Academy of Higher Education, Manipal, Karnatka, India.
Department of Microbiology, Kasturba Medical College, Manipal. Manipal Academy of Higher Education, Manipal, Karnataka, India.
Infect Ecol Epidemiol. 2024 Oct 15;14(1):2406834. doi: 10.1080/20008686.2024.2406834. eCollection 2024.
Hepatitis E Virus is a major cause of acute and fulminant hepatitis, particularly in developing countries. While the virus is commonly spread through the fecal-oral route, numerous cases of transfusion transmitted Hepatitis E Virus (TT-HEV) have been reported, raising concerns about its transmission via blood transfusions, especially in industrialized countries. The high prevalence of antibodies and viremia among asymptomatic blood donors further heightens the risk of transfusion-related transmission. However, there is still debate about the best strategy to minimize TT-HEV.
The review was conducted to Summarize the literature on TT-HEV infection cases and the prevalence of HEV among blood donors.
The databases PubMed, Scopus, Web of Science, Embase, and CINAHL were searched for relevant studies from 2000 to 2022.Serological and molecular screening data of HEV in blood donors were used to gather prevalence and incidence rates.TT-HEV cases were reviewed by examining evidence of HEV infection before and after transfusion.
A total of 121 manuscripts reports the prevalence and incidence of HEV among blood donors and cases of TT-HEV. Twenty-six articles reported confirmed cases of TT-HEV and 101 articles reported on HEV prevalence or incidence among blood donors.
TT-HEV transmission through blood products is a real concern, especially for immunocompromised patients.The risk and severity of infection could vary between immunocompetent and immunosuppressed patients.To increase transfusion safety, the evaluation recommends HEV screening protocols, especially in endemic region.
戊型肝炎病毒是急性和暴发性肝炎的主要病因，在发展中国家尤为如此。虽然该病毒通常通过粪-口途径传播，但已有大量输血传播戊型肝炎病毒（TT-HEV）病例的报道，这引发了人们对其通过输血传播的担忧，尤其是在工业化国家。无症状献血者中抗体和病毒血症的高流行率进一步增加了输血相关传播的风险。然而，关于将TT-HEV风险降至最低的最佳策略仍存在争议。
进行该综述以总结关于TT-HEV感染病例及献血者中戊型肝炎病毒流行情况的文献。
检索了PubMed、Scopus、科学网、Embase和CINAHL数据库，以查找2000年至2022年的相关研究。使用献血者中戊型肝炎病毒的血清学和分子筛查数据来收集流行率和发病率。通过检查输血前后戊型肝炎病毒感染的证据来回顾TT-HEV病例。
共有121篇手稿报告了献血者中戊型肝炎病毒的流行率和发病率以及TT-HEV病例。26篇文章报告了确诊的TT-HEV病例，101篇文章报告了献血者中戊型肝炎病毒的流行率或发病率。
通过血液制品传播TT-HEV是一个切实令人担忧的问题，尤其是对于免疫功能低下的患者。免疫功能正常和免疫抑制患者的感染风险和严重程度可能有所不同。为提高输血安全性，该评价建议采用戊型肝炎病毒筛查方案，尤其是在流行地区。
