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用于神经外科手术的集成显微镜的兆赫兹光学相干断层扫描系统：开发与临床体内成像

Microscope integrated MHz optical coherence tomography system for neurosurgery: development and clinical in-vivo imaging.

作者信息

Draxinger Wolfgang, Detrez Nicolas, Strenge Paul, Danicke Veit, Theisen-Kunde Dirk, Schützeck Lion, Spahr-Hess Sonja, Kuppler Patrick, Kren Jessica, Wieser Wolfgang, Mario Bonsanto Matteo, Brinkmann Ralf, Huber Robert

机构信息

Universität zu Lübeck, Institut für Biomedizinische Optik (BMO), Peter-Monnik-Weg 4, 23562 Lübeck, Germany.

Optores GmbH, Gollierstr. 70, 80339 Munich, Germany.

出版信息

Biomed Opt Express. 2024 Sep 23;15(10):5960-5979. doi: 10.1364/BOE.530976. eCollection 2024 Oct 1.

DOI:10.1364/BOE.530976
PMID:39421776
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11482179/
Abstract

Neurosurgical interventions on the brain are impeded by the requirement to keep damages to healthy tissue at a minimum. A new contrast channel enhancing the visual separation of malign tissue should be created. A commercially available surgical microscope was modified with adaptation optics adapting the MHz speed optical coherence tomography (OCT) imaging system developed in our group. This required the design of a scanner optics and beam delivery system overcoming constraints posed by the mechanical and optical parameters of the microscope. High quality volumetric OCT C-scans with dense sample spacing can be acquired in-vivo as part of surgical procedures within seconds and are immediately available for post-processing.

摘要

对大脑进行神经外科手术时，需要将对健康组织的损伤降至最低，这阻碍了手术的进行。应创建一个新的对比度通道，以增强恶性组织的视觉分离效果。我们对一台商用手术显微镜进行了改装，配备了适配光学器件，适配了我们团队开发的兆赫兹速度光学相干断层扫描（OCT）成像系统。这需要设计一种扫描光学器件和光束传输系统，以克服显微镜的机械和光学参数所带来的限制。作为手术过程的一部分，高质量的、具有密集样本间距的体层OCT C扫描可以在数秒内进行体内采集，并可立即用于后处理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b4/11482179/ea3f7aaa2bde/boe-15-10-5960-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b4/11482179/fc3a6929d592/boe-15-10-5960-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b4/11482179/15a1e15cf8c9/boe-15-10-5960-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b4/11482179/3d5d3f75bdde/boe-15-10-5960-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b4/11482179/0d48fa5ac241/boe-15-10-5960-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b4/11482179/858646f17d56/boe-15-10-5960-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b4/11482179/a7a9e2411a9a/boe-15-10-5960-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b4/11482179/7c29b77f7e37/boe-15-10-5960-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b4/11482179/ea3f7aaa2bde/boe-15-10-5960-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b4/11482179/fc3a6929d592/boe-15-10-5960-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b4/11482179/24c08af1f05a/boe-15-10-5960-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b4/11482179/0b2c58b12613/boe-15-10-5960-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b4/11482179/2d1ded511a21/boe-15-10-5960-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b4/11482179/1a017c3d177f/boe-15-10-5960-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b4/11482179/15a1e15cf8c9/boe-15-10-5960-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b4/11482179/3d5d3f75bdde/boe-15-10-5960-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b4/11482179/0d48fa5ac241/boe-15-10-5960-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b4/11482179/858646f17d56/boe-15-10-5960-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b4/11482179/a7a9e2411a9a/boe-15-10-5960-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b4/11482179/7c29b77f7e37/boe-15-10-5960-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b4/11482179/ea3f7aaa2bde/boe-15-10-5960-g012.jpg

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