Nuclear Medicine Department, The First Affiliated Hospital of Yangtze University and Health Science Center of Yangtze University, Jingzhou, Hubei 434023, P.R. China.
Department of Pathophysiology, School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, Hubei 434023, P.R. China.
Oncol Rep. 2024 Dec;52(6). doi: 10.3892/or.2024.8824. Epub 2024 Oct 18.
Bone metastasis (BM) is a common complication of cancer and contributes to a higher mortality rate in patients with cancer. The treatment of BM remains a significant challenge for oncologists worldwide. The colony‑stimulating factor (CSF) has an important effect on the metastasis of multiple cancers. studies have shown that CSF acts as a cytokine, promoting the colony formation of hematopoietic cells by activating granulocytes and macrophages. Other studies have shown that CSF not only promotes cancer aggressiveness but also correlates with the development and prognosis of various types of cancer. In recent years, the effect of CSF on BM has been primarily investigated using cellular and animal models, with limited clinical studies available. The present review discussed the composition and function of CSF, as well as its role in the progression of BM across various types of cancer. The mechanisms by which osteoclast‑ and osteoblast‑mediated BM occur are comprehensively described. In addition, the mechanisms of action of emerging therapeutic agents are explored for their potential clinical applications. However, further clinical studies are required to validate these findings.
骨转移（BM）是癌症的常见并发症，导致癌症患者的死亡率更高。全球肿瘤学家在治疗 BM 方面仍然面临重大挑战。集落刺激因子（CSF）对多种癌症的转移有重要影响。研究表明，CSF 作为细胞因子，通过激活粒细胞和巨噬细胞促进造血细胞的集落形成。其他研究表明，CSF 不仅促进癌症侵袭性，而且与各种类型癌症的发展和预后相关。近年来，主要使用细胞和动物模型研究 CSF 对 BM 的影响，临床研究有限。本综述讨论了 CSF 的组成和功能，以及其在各种类型癌症的 BM 进展中的作用。全面描述了破骨细胞和成骨细胞介导的 BM 发生的机制。此外，还探讨了新兴治疗药物的作用机制及其在临床应用中的潜力。然而，需要进一步的临床研究来验证这些发现。
