State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
Sichuan Provincial Engineering Research Center of Oral Biomaterials, Chengdu, Sichuan 610041, China.
ACS Appl Mater Interfaces. 2024 Oct 30;16(43):58477-58488. doi: 10.1021/acsami.4c14928. Epub 2024 Oct 18.
Sepsis is a disease with high morbidity and mortality, for which effective treatments are lacking. In recent years, microRNAs (miRs) have been shown to regulate numerous biological processes and can function as therapeutic options for various diseases. However, the poor stability and cell entry properties of miRs have greatly limited their clinical application. In this study, we developed a tetrahedral framework nucleic acid (tFNA)-based bioswitchable miR delivery system (BiRDS) to deliver miR-150 for the treatment of sepsis. BiRDS showed anti-inflammatory effects both and by regulating the NF-κB and Notch1 pathways. Therefore, this system holds promise as an ideal candidate for tackling systemic inflammation and multiorgan dysfunction in septic patients in the future.
脓毒症是一种发病率和死亡率都很高的疾病，目前缺乏有效的治疗方法。近年来，microRNAs（miRs）已被证明可以调节许多生物过程，并可以作为各种疾病的治疗选择。然而，miRs 的稳定性差和细胞进入特性极大地限制了它们的临床应用。在本研究中，我们开发了一种基于四面体框架核酸（tFNA）的生物可切换 miR 传递系统（BiRDS），用于递送 miR-150 以治疗脓毒症。BiRDS 通过调节 NF-κB 和 Notch1 通路发挥抗炎作用。因此，该系统有望成为未来治疗脓毒症患者全身炎症和多器官功能障碍的理想候选药物。
