Takamitsu Y, Kunau R T
Am J Physiol. 1986 Jan;250(1 Pt 2):F97-102. doi: 10.1152/ajprenal.1986.250.1.F97.
Administration of indomethacin or meclofenamate to normal rats increases renal papillary solute concentration primarily by enhancing solute addition. A reduction in papillary solute concentration is characteristic of potassium deficiency. Of the multiple factors probably responsible for this reduction, several can be influenced by indomethacin or meclofenamate. The present study examined the effect of indomethacin on papillary solute concentration in the potassium-deficient rat. Indomethacin increased papillary solute concentration in normal but not potassium-deficient rats when studied in the conscious hydropenic state. Since indomethacin could increase papillary plasma flow in the potassium-deficient rat, potentially negating any enhancement of solute transport into the papilla, papillary plasma flow and papillary Cl concentration were determined in anesthetized surgically manipulated rats. Base-line papillary Cl concentrations were reduced in this setting. Indomethacin increased papillary plasma flow only in potassium-deficient rats but increased papillary Cl concentration equivalently in normal and potassium-deficient rats. The ability of indomethacin to increase papillary solute concentration in the potassium-deficient rat seemingly depends upon the experimental setting.
给正常大鼠注射吲哚美辛或甲氯芬那酸主要通过增强溶质添加来提高肾乳头溶质浓度。钾缺乏的特征是肾乳头溶质浓度降低。在可能导致这种降低的多种因素中，有几种可受吲哚美辛或甲氯芬那酸影响。本研究检测了吲哚美辛对钾缺乏大鼠肾乳头溶质浓度的影响。在清醒禁水状态下进行研究时，吲哚美辛可提高正常大鼠而非钾缺乏大鼠的肾乳头溶质浓度。由于吲哚美辛可增加钾缺乏大鼠的肾乳头血浆流量，这可能会抵消溶质向肾乳头转运的任何增强作用，因此在麻醉下经手术操作的大鼠中测定了肾乳头血浆流量和肾乳头氯离子浓度。在此情况下，基线肾乳头氯离子浓度降低。吲哚美辛仅在钾缺乏大鼠中增加肾乳头血浆流量，但在正常大鼠和钾缺乏大鼠中同等程度地增加肾乳头氯离子浓度。吲哚美辛在钾缺乏大鼠中提高肾乳头溶质浓度的能力似乎取决于实验设置。
