Tuma R F, Vasthare U S, Irion G L, Wiedeman M P
Am J Physiol. 1986 Jan;250(1 Pt 2):H137-43. doi: 10.1152/ajpheart.1986.250.1.H137.
The results of single injections of different doses of microspheres (60,000, 100,000, and 375,000) demonstrated a significant reduction in measured heart and kidney blood flows as a function of the number of microspheres injected. Measured flow to other organs was unaffected by a single injection of these doses of microspheres. The injection of microspheres at a faster rate (0.8 ml/min microsphere injection; 1.0 ml/min flush) resulted in higher calculated heart flow when compared with the slow rate (0.2 ml/min microsphere injection; 0.25 ml/min flush). A significant decrease (approximately 21%) in measured blood flow to the right side of the brain that was observed in all the groups is due to the occlusion of the right carotid artery by the cannulation procedure. Intra-aortic injection of microspheres resulted in reduced measured brain blood flow when compared with intraventricular injections. Accurate and reliable heart and brain blood flows were not obtained with intra-aortic injection of microspheres. However, intra-aortic injection of microspheres does provide accurate and reliable flow measurements for more distal organs.
单次注射不同剂量微球（60,000、100,000和375,000）的结果表明，所测心脏和肾脏血流量随微球注射数量的增加而显著降低。单次注射这些剂量的微球对其他器官的所测血流量没有影响。与较慢注射速率（0.2 ml/分钟微球注射；0.25 ml/分钟冲洗）相比，较快的微球注射速率（0.8 ml/分钟微球注射；1.0 ml/分钟冲洗）导致计算出的心脏血流量更高。在所有组中观察到右侧大脑所测血流量显著下降（约21%），这是由于插管操作导致右颈动脉闭塞所致。与脑室内注射相比，主动脉内注射微球导致所测脑血流量减少。主动脉内注射微球无法获得准确可靠的心脏和脑血流量。然而，主动脉内注射微球确实能为更远端的器官提供准确可靠的血流量测量。
