Clark N B, Mok L L
Am J Physiol. 1986 Jan;250(1 Pt 2):R41-50. doi: 10.1152/ajpregu.1986.250.1.R41.
Renal clearance experiments were performed on herring gull (Larus argentatus) and great black-backed gull chicks (L. marinus) to test the importance of parathyroid hormone (PTH), parathyroidectomy (PTX), and calcium loading on excretion patterns of sodium, potassium, calcium, and phosphate. PTX reduced the relative clearance of phosphate to near zero within 2 h. Conversely, PTH stimulated net secretion of phosphate within 40 min. Calcium loading caused a drop in phosphate excretion identical to that of PTX, presumably by inhibiting PTH secretion by the parathyroid glands. This also could be reversed by administration of PTH. Serum phosphate values were highest in PTX gulls and lowest in calcium-loaded gulls. The relative clearance of calcium (CCa/CIn) was elevated in calcium-loaded birds. However, CCa/CIn did not change significantly in response to either PTX or PTH in the sham-operated or PTX birds. Serum calcium values were highest in calcium-loaded gulls and lowest in PTX gulls, the reciprocal of the effects on serum phosphate.
对银鸥（Larus argentatus）和大黑背鸥雏鸟（L. marinus）进行了肾脏清除实验，以测试甲状旁腺激素（PTH）、甲状旁腺切除术（PTX）和钙负荷对钠、钾、钙和磷酸盐排泄模式的重要性。PTX在2小时内将磷酸盐的相对清除率降低至接近零。相反，PTH在40分钟内刺激磷酸盐的净分泌。钙负荷导致磷酸盐排泄量下降，与PTX的情况相同，推测是通过抑制甲状旁腺分泌PTH。给予PTH也可使其逆转。PTX处理的海鸥血清磷酸盐值最高，钙负荷处理的海鸥血清磷酸盐值最低。钙负荷的鸟类中钙的相对清除率（CCa/CIn）升高。然而，在假手术或PTX处理的鸟类中，CCa/CIn对PTX或PTH均无显著变化。钙负荷处理的海鸥血清钙值最高，PTX处理的海鸥血清钙值最低，与对血清磷酸盐的影响相反。
