Departamento de Clínica e Odontologia Preventiva & Oral Medicine Unit, Hospital das Clínicas, Universidade Federal de Pernambuco, Recife, Brazil.
Unit of Oral and Maxillofacial Surgery, Ca' Foncello Hospital, Treviso, Italy.
Photobiomodul Photomed Laser Surg. 2024 Oct;42(10):609-619. doi: 10.1089/photob.2023.0155.
This study aimed to review the current body of literature on underexplored areas of photobiomodulation (PBM) for preventing and/or treating oral adverse events. Recent studies suggest that PBM may offer potential benefits in managing cancer-related toxicities other than oral mucositis. Nevertheless, further research to establish conclusive evidence is still missing. A panel of specialists conducted a narrative review to evaluate the evidence on PBM therapy for oral mucositis, xerostomia, dysgeusia, dysphagia, and trismus/fibrosis. Each topic was reviewed by two specialists who discussed treatment rationale, summarized current evidence, evaluated risk/benefit ratio, and identified future research directions. The current evidence suggests promising outcomes in nonroutine uses of PBM for xerostomia, dysgeusia, odynophagia, oral mucositis (extraoral PBM and the pediatric population), and trismus/fibrosis. However, the primary studies are often small and may have biases that require further evaluation, particularly regarding treatment safety. Despite the overall positive impression of PBM therapy for oral adverse events of cancer treatment, robust evidence from large multicentered studies is necessary to support its widespread clinical use.
本研究旨在综述光生物调节（PBM）在预防和/或治疗口腔不良反应方面的研究现状。最近的研究表明，PBM 可能对管理除口腔黏膜炎以外的癌症相关毒性具有潜在益处。然而，仍需要进一步的研究来确定确凿的证据。一组专家进行了叙述性综述，以评估 PBM 疗法治疗口腔黏膜炎、口干症、味觉障碍、吞咽困难和牙关紧闭/纤维化的证据。每个主题都由两名专家进行审查，他们讨论了治疗原理、总结了当前的证据、评估了风险/收益比，并确定了未来的研究方向。目前的证据表明，PBM 治疗口干症、味觉障碍、吞咽困难、口腔黏膜炎（体外 PBM 和儿科人群）和牙关紧闭/纤维化的非常规用途有较好的结果。然而，主要研究通常规模较小，可能存在需要进一步评估的偏倚，特别是关于治疗安全性。尽管 PBM 治疗癌症治疗的口腔不良反应总体印象良好，但仍需要来自大型多中心研究的强有力证据来支持其广泛的临床应用。
