Li Yang, Wen Jialin, Jiang Qianqian, Cui Hong
Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Clin Pediatr (Phila). 2025 Jun;64(6):780-790. doi: 10.1177/00099228241289739. Epub 2024 Oct 18.
This study aimed to describe the growth pattern in preterm infants and identify factors influencing catch-up growth. A total of 288 preterm infants were divided into groups based on the degree of prematurity, sex, and size for gestational age. Growth in head circumference, length, weight-for-length, and weight was compared between groups at corrected age of 0, 3, 6, 9, 12, 18, and 24 months. Logistic regression analysis was conducted to determine risk factors for catch-up growth. At a corrected age of 24 months, the proportions of preterm infants with z-scores less than -2 for head circumference, length, weight-for-length, and weight were less than the expected 2.3% at 0.9%, 1.7%, 2.1%, and 1.7%, respectively. The head circumference, length, weight-for-length, and weight z-scores at corrected ages of 24 months were lower in the small for gestational age (SGA) group than in the non-SGA group ( < .05). The weight-for-length z-scores were higher in the late preterm birth infants than in the very preterm birth infants at a corrected age of 24 months ( < .05). At a corrected age 24 months, the proportion of male with weight z-scores <-2 was lower than that of female ( < .05). The differences in proportion of the z-scores (head circumference, length, weight-for-length, and weight) <-2 at a corrected age of 24 months among different gestational age groups and intrauterine growth status groups were not statistically significant ( > .05). We found that the factors influencing catch-up growth in preterm infants varied at different corrected age stages, and the impact of factors during hospitalization gradually diminished as the infants grew.
本研究旨在描述早产儿的生长模式,并确定影响追赶生长的因素。总共288名早产儿根据早产程度、性别和胎龄大小分组。在矫正年龄0、3、6、9、12、18和24个月时比较各组头围、身长、身长体重比和体重的增长情况。进行逻辑回归分析以确定追赶生长的危险因素。在矫正年龄24个月时,头围、身长、身长体重比和体重的z评分小于-2的早产儿比例分别为0.9%、1.7%、2.1%和1.7%,低于预期的2.3%。小于胎龄(SGA)组矫正年龄24个月时的头围、身长、身长体重比和体重z评分低于非SGA组(P<0.05)。矫正年龄24个月时,晚期早产儿的身长体重比z评分高于极早早产儿(P<0.05)。矫正年龄24个月时,体重z评分<-2的男性比例低于女性(P<0.05)。不同胎龄组和宫内生长状况组在矫正年龄24个月时z评分(头围、身长、身长体重比和体重)<-2的比例差异无统计学意义(P>0.05)。我们发现,影响早产儿追赶生长的因素在不同矫正年龄阶段有所不同,住院期间各因素的影响随着婴儿长大逐渐减弱。