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极早产儿和小于胎龄儿不同的追赶生长模式。

Different Catch-Up Growth Patterns in Very Preterm and Small for Gestational Age Infants.

作者信息

Li Yang, Wen Jialin, Jiang Qianqian, Cui Hong

机构信息

Beijing Friendship Hospital, Capital Medical University, Beijing, China.

出版信息

Clin Pediatr (Phila). 2025 Jun;64(6):780-790. doi: 10.1177/00099228241289739. Epub 2024 Oct 18.

Abstract

This study aimed to describe the growth pattern in preterm infants and identify factors influencing catch-up growth. A total of 288 preterm infants were divided into groups based on the degree of prematurity, sex, and size for gestational age. Growth in head circumference, length, weight-for-length, and weight was compared between groups at corrected age of 0, 3, 6, 9, 12, 18, and 24 months. Logistic regression analysis was conducted to determine risk factors for catch-up growth. At a corrected age of 24 months, the proportions of preterm infants with z-scores less than -2 for head circumference, length, weight-for-length, and weight were less than the expected 2.3% at 0.9%, 1.7%, 2.1%, and 1.7%, respectively. The head circumference, length, weight-for-length, and weight z-scores at corrected ages of 24 months were lower in the small for gestational age (SGA) group than in the non-SGA group ( < .05). The weight-for-length z-scores were higher in the late preterm birth infants than in the very preterm birth infants at a corrected age of 24 months ( < .05). At a corrected age 24 months, the proportion of male with weight z-scores <-2 was lower than that of female ( < .05). The differences in proportion of the z-scores (head circumference, length, weight-for-length, and weight) <-2 at a corrected age of 24 months among different gestational age groups and intrauterine growth status groups were not statistically significant ( > .05). We found that the factors influencing catch-up growth in preterm infants varied at different corrected age stages, and the impact of factors during hospitalization gradually diminished as the infants grew.

摘要

本研究旨在描述早产儿的生长模式,并确定影响追赶生长的因素。总共288名早产儿根据早产程度、性别和胎龄大小分组。在矫正年龄0、3、6、9、12、18和24个月时比较各组头围、身长、身长体重比和体重的增长情况。进行逻辑回归分析以确定追赶生长的危险因素。在矫正年龄24个月时,头围、身长、身长体重比和体重的z评分小于-2的早产儿比例分别为0.9%、1.7%、2.1%和1.7%,低于预期的2.3%。小于胎龄(SGA)组矫正年龄24个月时的头围、身长、身长体重比和体重z评分低于非SGA组(P<0.05)。矫正年龄24个月时,晚期早产儿的身长体重比z评分高于极早早产儿(P<0.05)。矫正年龄24个月时,体重z评分<-2的男性比例低于女性(P<0.05)。不同胎龄组和宫内生长状况组在矫正年龄24个月时z评分(头围、身长、身长体重比和体重)<-2的比例差异无统计学意义(P>0.05)。我们发现,影响早产儿追赶生长的因素在不同矫正年龄阶段有所不同,住院期间各因素的影响随着婴儿长大逐渐减弱。

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