Rao C C, Boyer M S, Krishna G, Paradise R R
Anesthesiology. 1986 Jan;64(1):13-8. doi: 10.1097/00000542-198601000-00003.
Isolated atria from neonatal (0-5 day old) and adult (50 +/- 5 day old) rats were perifused in oxygenated Kreb's Henseleit solution at 30 +/- 0.5 degrees C and exposed to four different concentrations of halothane, isoflurane, or enflurane while isometric contractile tension was recorded and compared with control atria. ED50 values (mM of anesthetic required to produce 50% reduction in contractile tension) of neonates for halothane (0.18 +/- 0.01), isoflurane (0.41 +/- 0.05), and enflurane (0.41 +/- 0.04) were significantly lower than those of adults (0.35 +/- 0.02, 0.80 +/- 0.05, and 1.15 +/- 0.05, respectively). Furthermore, neonatal ED50 calculated as per cent of adult ED50 was significantly less for enflurane (35%) than for halothane (54%) or isoflurane (51%).
将新生（0 - 5日龄）和成年（50±5日龄）大鼠的离体心房在30±0.5℃的充氧克雷布斯 - 亨塞尔特溶液中进行灌流，并暴露于四种不同浓度的氟烷、异氟烷或恩氟烷中，同时记录等长收缩张力，并与对照心房进行比较。新生大鼠对氟烷（0.18±0.01）、异氟烷（0.41±0.05）和恩氟烷（0.41±0.04）的ED50值（使收缩张力降低50%所需的麻醉剂毫摩尔数）显著低于成年大鼠（分别为0.35±0.02、0.80±0.05和1.15±0.05）。此外，以成年大鼠ED50的百分比计算，新生大鼠恩氟烷的ED50（35%）显著低于氟烷（54%）或异氟烷（51%）。
