Department of Pediatric Infectious Diseases and Immunology, AI&II, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Pediatric Intensive Care Unit, Departments of Pediatrics and Pediatric Surgery, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.
Eur J Pediatr. 2024 Dec;183(12):5441-5453. doi: 10.1007/s00431-024-05819-6. Epub 2024 Oct 18.
To investigate daily functioning, health-related quality of life (HRQoL), and overall quality of life (QoL) in young adult survivors of childhood bacterial meningitis (BM) thereby shedding light on very long-term outcomes and contributing to global meningitis burden estimates. In this cross-sectional study, the Weiss Functional Impairment Rating Scale-Self Report (WFIRS-S), the Patient-Reported Outcomes Measurement Information System Scale vGlobal Health v1.2 (PROMIS-GH), PROMIS-29 profile v2.01 and PROMIS Satisfaction with Social Roles and Activities Short Form 4a v2.0 instruments were administered to 483 survivors of childhood BM who participated in the 20|30 Dutch Postmeningitis study. Mean WFIRS-S scores were calculated as well as mean T-scores of the PROMIS instruments. PROMIS scores of survivors of childhood BM were compared with age-matched Dutch reference scores from the general population. Overall, survivors of childhood BM reported comparable or even better levels of daily functioning, HRQoL, and overall QoL (Global02) than the age-matched Dutch reference group. 10.2% of survivors of childhood BM reported poor mental health and 1.0% of survivors of childhood BM reported poor physical health. The average score of survivors of childhood BM for overall QoL (Global02) was 3.81 (on a scale from 1, indicating poor QoL, to 5, indicating excellent QoL).
Young adult survivors of childhood BM reported similar and even better levels of daily functioning, HRQoL, and overall QoL than age-matched Dutch reference scores. However, clinicians and healthcare workers should be mindful of poor mental and physical health of some survivors of childhood BM because these survivors also face problems with functioning in daily life.
• Acute bacterial meningitis is a life-threatening infection which may lead to devastating lifelong disabilities. • Health-related quality of life is decreased in school-age survivors of bacterial meningitis.
• The present study shows that HRQoL in survivors of childhood BM improves over time • However, especially poor mental health in adolescent and young adult survivors is associated with impaired functioning in daily life.
研究儿童细菌性脑膜炎（BM）后年轻成年幸存者的日常功能、健康相关生活质量（HRQoL）和总体生活质量（QoL），从而揭示其非常长期的结果，并为全球脑膜炎负担估计做出贡献。在这项横断面研究中，使用 Weiss 功能障碍评定量表-自我报告（WFIRS-S）、患者报告的结局测量信息系统量表 v 全球健康 v1.2（PROMIS-GH）、PROMIS-29 简表 v2.01 和 PROMIS 社交角色和活动满意度简短表 4a v2.0 工具对参加 20|30 荷兰脑膜炎后研究的 483 名儿童 BM 幸存者进行了评估。计算了 WFIRS-S 的平均得分和 PROMIS 工具的平均 T 评分。将儿童 BM 幸存者的 PROMIS 评分与年龄匹配的荷兰普通人群参考评分进行比较。总体而言，儿童 BM 幸存者报告的日常功能、HRQoL 和总体 QoL（Global02）水平与年龄匹配的荷兰参考组相当，甚至更好。10.2%的儿童 BM 幸存者报告心理健康状况较差，1.0%的儿童 BM 幸存者报告身体健康状况较差。儿童 BM 幸存者总体 QoL（Global02）的平均得分为 3.81（评分范围为 1 表示 QoL 较差，5 表示 QoL 较好）。
儿童 BM 后年轻成年幸存者报告的日常功能、HRQoL 和总体 QoL 水平与年龄匹配的荷兰参考评分相似，甚至更好。然而，临床医生和医疗保健工作者应该注意到一些儿童 BM 幸存者的心理健康和身体健康较差，因为这些幸存者在日常生活中也面临着功能障碍的问题。
急性细菌性脑膜炎是一种危及生命的感染，可能导致终身残疾。儿童细菌性脑膜炎患者的健康相关生活质量下降。
本研究表明，儿童 BM 后 HRQoL 随时间改善。然而，青少年和年轻成年幸存者的心理健康状况较差，与日常生活功能障碍有关。
