Department of Anesthesiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Department of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
Commun Biol. 2024 Oct 18;7(1):1350. doi: 10.1038/s42003-024-07058-9.
Offset responses are traditionally viewed as indicators of sound cessation. Here, we investigate offset responses to auditory click trains, examining how they are modulated by inter-click intervals (ICIs) and train duration. Using extracellular recordings and electrocorticography (ECoG) in non-human primates, alongside electroencephalography (EEG) in humans, we show that offset responses are significantly influenced by both ICI and train length, thereby establishing them as markers of temporal integration. We introduce the concept of the 'Neuronal Integrative Window' (NIW), defined as the temporal span during which neurons integrate stimuli to produce or modulate the temporal integration signal. Our data reveal that on the neuronal level, the auditory cortex (AC) exhibits a more expansive NIW than the medial geniculate body (MGB), integrating stimuli over longer durations and showing a preference for larger ICIs. Furthermore, our results indicate that offset responses could serve as potential biomarkers for neurological and psychiatric conditions, highlighted by their sensitivity to pharmacological modulation with ketamine. This study advances our understanding of auditory temporal processing and proposes a novel approach for assessing and monitoring brain health.
偏移响应传统上被视为声音停止的指标。在这里，我们研究了听觉点击序列的偏移响应，考察了它们如何被点击间隔 (ICIs) 和序列长度调制。使用非人类灵长类动物的细胞外记录和皮层电图 (ECoG) 以及人类的脑电图 (EEG)，我们表明，偏移响应受 ICI 和序列长度的显著影响，从而将其确立为时间整合的标志物。我们引入了“神经元整合窗口”(NIW)的概念，将其定义为神经元整合刺激以产生或调制时间整合信号的时间跨度。我们的数据表明，在神经元水平上，听觉皮层 (AC) 比内侧膝状体 (MGB) 表现出更广阔的 NIW，能够整合更长时间的刺激，并表现出对更大 ICI 的偏好。此外，我们的结果表明，偏移响应可以作为神经和精神疾病的潜在生物标志物，其对氯胺酮的药物调节敏感突出了这一点。这项研究推进了我们对听觉时间处理的理解，并提出了一种评估和监测大脑健康的新方法。
