Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Department of Psychiatry, Huashan Hospital, Fudan University, Shanghai, 200040, China.
BMC Psychiatry. 2024 Oct 18;24(1):700. doi: 10.1186/s12888-024-06118-y.
Second-generation antipsychotic drugs are increasingly used to treat depressive disorders with psychotic symptoms. In addition to effectively managing psychotic symptoms, second-generation antipsychotics can also result in adverse drug reactions in patients, which should not be underestimated.
We report the case of 14 years old unmarried female patient with depression. At first, she started with moping and gradually developed into self-injury and whispering. After antidepressant treatment combined with the second-generation antipsychotic drug blonanserin, the patient's psychotic and depressive symptoms improved significantly, while the patient developed lactation, which stopped after the medication was changed.
Although Blonanserin's clinical trials have reported rare adverse reactions like elevated prolactin levels and even lactation, caution is still needed in clinical application of the drug. This case is expected to improve psychiatrists' choice of antidepressant therapy in combination with antipsychotic drugs.
第二代抗精神病药物越来越多地被用于治疗伴有精神病症状的抑郁症。除了能有效治疗精神病症状外，第二代抗精神病药物还可能导致患者出现药物不良反应，这一点不容忽视。
我们报告了一例 14 岁未婚女性抑郁症患者的病例。起初，她开始闷闷不乐，逐渐发展为自残和自言自语。在接受抗抑郁药联合第二代抗精神病药物阿立哌唑治疗后，患者的精神病和抑郁症状明显改善，但患者出现了泌乳，停药后泌乳停止。
虽然阿立哌唑的临床试验报告了罕见的不良反应，如催乳素水平升高，甚至泌乳，但在临床应用该药时仍需谨慎。本病例有望改善精神科医生在联合使用抗精神病药物时对抗抑郁治疗的选择。
