Department of Neonatology, Children's Medical Center, The First Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
FASEB J. 2024 Oct 31;38(20):e70122. doi: 10.1096/fj.202401323R.
The intestine is a hollow tract that primarily transports and digests food. It often encounters mechanical forces and exotic threats, resulting in increased intestinal inflammation attributed to the consistent threat of foreign pathogens. Piezo1, a mechanosensitive ion channel, is distributed broadly and abundantly in the intestinal tissue. It transduces mechanical signals into electrochemical signals and participates in many critical life activities, such as proliferation, differentiation, cell apoptosis, immune cell activation, and migration. Its effect on inflammation has been discussed in detail in systems, such as musculoskeletal (osteoarthritis) and cardiac (myocarditis), but the effects on intestinal inflammation remain unelucidated. Piezo1 regulates mucosal layer and epithelial barrier homeostasis during the complex intestinal handling of foreign antigens and tissue trauma. It initiates and spreads immune responses and causes distant effects of inflammation in the vascular and lymphatic systems, but reports of the effects of Piezo1 in intestinal inflammation are scarce. Therefore, this study aimed to discuss the role of Piezo1 in intestinal inflammation and explore novel therapeutic targets.
肠道是一条中空的管道，主要负责运输和消化食物。它经常受到机械力和外来威胁的影响，导致肠道炎症增加，这归因于持续存在的外来病原体的威胁。Piezo1 是一种机械敏感的离子通道，广泛而丰富地分布在肠道组织中。它将机械信号转化为电化学信号，并参与许多关键的生命活动，如增殖、分化、细胞凋亡、免疫细胞激活和迁移。Piezo1 对炎症的影响已在骨骼肌肉（骨关节炎）和心脏（心肌炎）等系统中进行了详细讨论，但对肠道炎症的影响仍不清楚。Piezo1 在肠道处理外来抗原和组织创伤的复杂过程中调节黏膜层和上皮屏障的稳态。它启动和传播免疫反应，并在血管和淋巴系统中引起远处的炎症效应，但关于 Piezo1 在肠道炎症中的作用的报道很少。因此，本研究旨在探讨 Piezo1 在肠道炎症中的作用，并探索新的治疗靶点。
