Laboratório de Cultura de Células do Delta (LCCDelta), Universidade Federal do Delta do Parnaíba, Parnaíba, Piauí, Brazil.
Cell Biochem Funct. 2024 Sep;42(7):e70001. doi: 10.1002/cbf.70001.
Cancer is the second leading cause of death worldwide and is considered a major public health problem. Despite the significant advances in cancer research, the conventional cancer treatment approaches often lead to serious side effects that affect the quality of life of cancer patients. Thus, searching for new alternatives for cancer treatment is crucial to minimize these problems. Chalcone-sulfonamide hybrids display a range of biological activities and have been widely investigated for their anticancer potential, being considered promising molecules for cancer treatment. This systematic review aimed to summarize the information available in the literature about the anticancer potential of chalcones-sulfonamides in vitro and in vivo and their mechanisms of action. Our analysis demonstrated that chalcones-sulfonamides have relevant cytotoxic potential against different cancer cell lines in vitro, especially against the human colorectal carcinoma cell line HCT-116. These molecules have also reduced tumor growth in vivo. Some chalcones-sulfonamides had improved cytotoxicity after chemical modification and could become more selective or even more potent than reference chemotherapeutics. The mechanisms underlying these effects demonstrated that chalcones-sulfonamides may lead to cell death by different pathways, predominantly via apoptosis or necroptosis. This review may encourage researchers to advance studies with chalcones-sulfonamides, especially to elucidate their mechanisms of action, contributing to the development of new alternatives to cancer treatment.
癌症是全球第二大死亡原因，被认为是一个主要的公共卫生问题。尽管癌症研究取得了重大进展，但传统的癌症治疗方法往往会导致严重的副作用，影响癌症患者的生活质量。因此，寻找新的癌症治疗方法至关重要，可以最大限度地减少这些问题。查尔酮-磺胺类混合物具有多种生物活性，其抗癌潜力已得到广泛研究，被认为是癌症治疗有前途的分子。本系统评价旨在总结文献中关于查尔酮-磺胺类化合物在体外和体内的抗癌潜力及其作用机制的信息。我们的分析表明，查尔酮-磺胺类化合物在体外对不同的癌细胞系具有重要的细胞毒性潜力，特别是对人结肠直肠癌细胞系 HCT-116。这些分子还能减少体内肿瘤的生长。一些查尔酮-磺胺类化合物经过化学修饰后，细胞毒性得到了提高，可能比参考化疗药物更具选择性甚至更有效。这些作用的机制表明，查尔酮-磺胺类化合物可能通过不同的途径导致细胞死亡，主要是通过细胞凋亡或坏死。这篇综述可能鼓励研究人员进一步研究查尔酮-磺胺类化合物，特别是阐明其作用机制，为癌症治疗的新方法的开发做出贡献。
