Aalam Alexandre-Amir, Krivitsky Aalam Alina, Yermian Nader, Choukroun Joseph
Clinical Associate Professor, Department of Advanced Periodontics, USC School of Dentistry, Los Angeles, California, USA.
Private Practice.
J Esthet Restor Dent. 2025 May;37(5):1184-1191. doi: 10.1111/jerd.13341. Epub 2024 Oct 19.
Platelet-rich fibrin (PRF) has had a marked impact on regenerative medicine due to its widespread ability to promote angiogenesis to defective tissues. Particularly in the dental field, evidence from randomized clinical trials has further shown that PRF facilitates greater soft-tissue regeneration when compared with hard tissues.
Recently, the fibrin-assisted soft-tissue promotion (FASTP) technique has been developed as a means to promote soft-tissue regeneration of mucogingival recessions utilizing PRF. Within the present case report, a 28-year-old male presented with multiple adjacent mucogingival recessions in the maxilla ranging in probing depths (1-3 mm) and gingival recessions (1-5 mm). For optimal regenerative outcomes, the use of advanced PRF (A-PRF; 1300 RPM for 8 min) has been utilized to enhance regenerative outcomes by fully taking advantage of the low-speed centrifugation concept (LSCC).
This case report highlights the latest surgical concepts, centrifugation protocols, and use of the LSCC to regenerate multiple adjacent mucogingival recessions in the esthetic zone.
富血小板纤维蛋白（PRF）因其具有广泛促进血管生成至缺损组织的能力，对再生医学产生了显著影响。特别是在牙科领域，随机临床试验的证据进一步表明，与硬组织相比，PRF更有助于促进软组织再生。
最近，纤维蛋白辅助软组织促进（FASTP）技术已被开发出来，作为利用PRF促进龈黏膜退缩软组织再生的一种手段。在本病例报告中，一名28岁男性上颌出现多个相邻的龈黏膜退缩，探诊深度为1至3毫米，牙龈退缩为1至5毫米。为了获得最佳的再生效果，采用了先进的PRF（A-PRF；1300转/分钟，持续8分钟），通过充分利用低速离心概念（LSCC）来提高再生效果。
本病例报告强调了最新的手术概念、离心方案以及利用LSCC再生美学区域多个相邻龈黏膜退缩的方法。
