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老年人住院后的药物不良反应:对全科医生观点的定性探索。

Adverse drug reactions in older people following hospitalisation: a qualitative exploration of general practitioners' perspectives.

作者信息

Cousins Justin M, Bereznicki Bonnie, Parameswaran Nair Nibu, Webber Elizabeth, Curtain Colin

机构信息

School of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS, Australia.

Tasmanian School of Medicine, University of Tasmania, Hobart, TAS, Australia.

出版信息

Int J Clin Pharm. 2025 Feb;47(1):60-67. doi: 10.1007/s11096-024-01806-x. Epub 2024 Oct 19.

Abstract

BACKGROUND

Older people have greater comorbidity and medication burden. Adverse drug reactions occur in up to 30% of older people within one month of hospital discharge. General practitioners are key stakeholders in transitions of care from hospital to the community.

AIM

The study aimed to explore general practitioner perspectives of adverse drug reactions in older people after hospitalisation, investigating the medication-related issues encountered and possible approaches to reduce the risk.

METHOD

An invitation to participate in the study was sent to general practitioners in Southern Tasmania, Australia. A semi-structured interview occurred in person at their practice or online. The questions covered experiences with managing medication in older people after hospital discharge, challenges and risks involving adverse drug reactions and suggestions to prevent adverse drug reactions. The interviews were transcribed and analysed through thematic analysis.

RESULTS

Twelve general practitioners were interviewed, revealing four themes describing challenges, including (i) complex patients and acceptance of risk, (ii) patient confusion and decline in hospital, (iii) time taken to manage older patients and (iv) communication challenges. Three themes describing recommendations were identified, including (i) clear communication on discharge, (ii) patient involvement and (iii) roles for pharmacists.

CONCLUSION

Prevention of adverse drug reactions after hospital discharge may require clear and timely communication to general practitioners, patients and families to be educated and empowered to help manage their own health and risk, and pharmacists to support both patients and general practitioners in managing the risks.

摘要

背景

老年人合并症更多,用药负担更重。高达30%的老年人在出院后一个月内会发生药物不良反应。全科医生是医院到社区护理过渡中的关键利益相关者。

目的

本研究旨在探讨全科医生对老年人住院后药物不良反应的看法,调查所遇到的与用药相关的问题以及降低风险的可能方法。

方法

向澳大利亚塔斯马尼亚州南部的全科医生发出参与研究的邀请。在他们的诊所进行面对面的半结构化访谈,或通过网络进行。问题涵盖出院后管理老年人用药的经验、药物不良反应涉及的挑战和风险以及预防药物不良反应的建议。访谈内容被转录并通过主题分析进行分析。

结果

对12名全科医生进行了访谈,揭示了描述挑战的四个主题,包括(i)复杂的患者和对风险的接受,(ii)患者困惑和住院期间的病情恶化,(iii)管理老年患者所需的时间,以及(iv)沟通挑战。确定了描述建议的三个主题,包括(i)出院时的清晰沟通,(ii)患者参与,以及(iii)药剂师的作用。

结论

出院后预防药物不良反应可能需要与全科医生、患者及其家属进行清晰及时的沟通,使他们得到教育并获得权力以帮助管理自身健康和风险,还需要药剂师支持患者和全科医生管理风险。

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