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特发性室性心动过速的靶向重离子放射治疗成功的交感神经调节案例。

Case of Successful Sympathetic Nerve Modulation by Targeted Heavy Ion Radiotherapy for Idiopathic Ventricular Tachycardia.

机构信息

Department of Cardiology, Tokai University School of Medicine, Isehara, Japan.

National Institute for Quantum Science and Technology, Inage, Japan.

出版信息

Ann Noninvasive Electrocardiol. 2024 Nov;29(6):e70020. doi: 10.1111/anec.70020.

Abstract

Non-invasive radioablation using stereotactic body radiation therapy with X-ray has been proposed as a rescue treatment for refractory ventricular tachycardia (VT). However, there are concerns about the occurrence of late valvular or coronary disease. We treated VT originating from the aortic sinus cusp using the Bragg peak principle of a heavy ion beam, minimizing the dose to the aortic valve and coronary artery and providing an anti-arrhythmic effect and cardiac function recovery due to improved sympathetic nerve heterogeneity. We present a method for targeting sympathetic nerve distribution using I-metaiodobenzylguanidine scintigraphy.

摘要

立体定向体部放射治疗结合 X 射线的无创性放射消融术已被提议作为难治性室性心动过速(VT)的抢救治疗方法。然而,人们对晚期瓣膜或冠状动脉疾病的发生仍存在担忧。我们使用重离子束的布拉格峰原理治疗起源于主动脉窦嵴的 VT,使主动脉瓣和冠状动脉的剂量最小化,并由于改善了交感神经异质性而提供抗心律失常作用和心脏功能恢复。我们提出了一种使用碘代间位碘苄胍闪烁显像术靶向支配神经分布的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f750/11490255/356aeed833f0/ANEC-29-e70020-g006.jpg

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