Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100037, China.
Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100037, China.
Int J Cardiol. 2025 Jan 1;418:132665. doi: 10.1016/j.ijcard.2024.132665. Epub 2024 Oct 18.
The fibrinogen-to-albumin ratio (FAR) has been identified as a new inflammatory marker for predicting the risk of cardiovascular diseases. Nevertheless, its prognostic relevance in patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) remains uncertain.
This study included a total of 1031 hospitalized patients diagnosed with MINOCA, enrolled consecutively. The primary outcome was the occurrence of major adverse cardiovascular events (MACE). Based on the median FAR value, patients were divided into high FAR (FARH) and low FAR (FAR-L) groups. Baseline clinical characteristics and the incidence of adverse events during the follow-up period were compared between the two groups. Various statistical methods were applied, including restricted cubic spline modeling, Kaplan-Meier survival analysis, and Cox proportional hazards modeling.
The median follow-up duration was 42.3 months, during which 157 patients (15.2 %) experienced MACE. The FAR-H group had a significantly higher incidence of MACE compared to the FAR-L group (21.2 % vs. 9.3 %, p < 0.001). Multivariate Cox regression analysis revealed that a higher FAR was an independent predictor of long-term MACE in MINOCA patients (hazard ratio = 2.76, 95 % confidence interval: 1.95-3.89, p < 0.001), after adjusting for relevant clinical variables.
An elevated FAR is linked to a poor long-term prognosis in patients with MINOCA.
纤维蛋白原与白蛋白比值（FAR）已被确定为预测心血管疾病风险的新型炎症标志物。然而，其在非阻塞性冠状动脉心肌梗死（MINOCA）患者中的预后相关性尚不确定。
本研究共纳入了 1031 例连续住院诊断为 MINOCA 的患者。主要结局为主要不良心血管事件（MACE）的发生。根据 FAR 的中位数，患者被分为高 FAR（FARH）和低 FAR（FAR-L）组。比较两组患者的基线临床特征和随访期间不良事件的发生率。应用了多种统计方法，包括限制性立方样条模型、Kaplan-Meier 生存分析和 Cox 比例风险模型。
中位随访时间为 42.3 个月，期间 157 例（15.2%）患者发生了 MACE。FARH 组的 MACE 发生率明显高于 FAR-L 组（21.2% vs. 9.3%，p<0.001）。多变量 Cox 回归分析显示，较高的 FAR 是 MINOCA 患者长期发生 MACE 的独立预测因素（危险比=2.76，95%置信区间：1.95-3.89，p<0.001），校正了相关临床变量后。
FAR 升高与 MINOCA 患者的不良长期预后相关。
