Liu Zhengfeng, Pan Xuemei, Wang Dan, Zou Yingying, Liu Peipei, Wang Ying, Bi Hongsheng, Xie Xiaofeng
Shandong University of Traditional Chinese Medicine, Jinan 250355 Shandong Province, PR China.
Shandong University of Traditional Chinese Medicine Affiliated Eye Hospital, Jinan 250002 Shandong Province, PR China.
Photodiagnosis Photodyn Ther. 2024 Dec;50:104380. doi: 10.1016/j.pdpdt.2024.104380. Epub 2024 Oct 18.
To observe the clinical features of the paracentral acute middle maculopathy (PAMM) and to investigate the changes in perfusion density of superficial capillary plexus (SCP) and deep capillary plexus (DCP) in PAMM by optical coherence tomography angiography (OCTA).
Twelve patients (12 eyes) diagnosed with PAMM and 13 healthy participants (13 eyes) were enrolled. The clinical features of 12 PAMM patients were recorded. The perfusion density of SCP and DCP in the parafovea and perifovea (divided into Temporal, Superior, Nasal, and Inferior) was measured by OCTA in PAMM and healthy eyes. Automated macular maps, including SCP and DCP, were also performed.
The mean age of patients was 48.08 (range 14-72) years. The best corrected visual acuity (BCVA) was from finger count (FC) to 1.0. Risk factors included hypertension, diabetes mellitus, COVID-19, etc. The patients had signs of retinal vascular disease except for one patient with isolated PAMM. A spectral-domain OCT image of the PAMM eye showed hyperreflectivity in the inner nuclear layer (INL). Compared with healthy eyes, SCP and DCP in PAMM eyes were significantly reduced in all sectors (all p < 0.05) in the parafovea and perifovea. The average perfusion density of SCP in parafovea and perifovea in PAMM eyes were 46.94±4.34% vs 52.21±3.98 % (p = 0.002), 44.01±3.95% vs 50.51±3.14 (p = 0.000) in healthy eyes. The average perfusion density of DCP in parafovea and perifovea in PAMM eyes were 51.22±4.16% vs 57.15±3.87 % (p = 0.002), 47.375±6.23% vs 54.27±5.33 % (p = 0.002) in healthy eyes.
PAMM often accompanies concurrent ocular and systemic diseases. OCTA results confirm that the perfusion density of SCP and DCP in the parafovea and perifovea significantly reduced in PAMM patients.
观察中心旁急性黄斑病变（PAMM）的临床特征，并通过光学相干断层扫描血管造影（OCTA）研究PAMM患者浅表毛细血管丛（SCP）和深部毛细血管丛（DCP）的灌注密度变化。
纳入12例诊断为PAMM的患者（12只眼）和13名健康参与者（13只眼）。记录12例PAMM患者的临床特征。通过OCTA测量PAMM患者和健康对照者黄斑中心凹旁和黄斑中心凹周围（分为颞侧、上方、鼻侧和下方）SCP和DCP的灌注密度。还进行了包括SCP和DCP在内的自动黄斑地图分析。
患者的平均年龄为48.08岁（范围14 - 72岁）。最佳矫正视力（BCVA）从指数（FC）到1.0。危险因素包括高血压、糖尿病、COVID - 19等。除1例孤立性PAMM患者外，其余患者均有视网膜血管疾病体征。PAMM患眼的频域OCT图像显示内核层（INL）高反射。与健康对照眼相比，PAMM患眼黄斑中心凹旁和黄斑中心凹周围所有象限的SCP和DCP均显著降低（所有p < 0.05）。PAMM患眼黄斑中心凹旁和黄斑中心凹周围SCP的平均灌注密度分别为46.94±4.34%和52.21±3.98%（p = 0.002），健康对照眼为44.01±3.95%和50.51±3.14（p = 0.000）。PAMM患眼黄斑中心凹旁和黄斑中心凹周围DCP的平均灌注密度分别为51.22±4.16%和57.15±3.87%（p = 0.002），健康对照眼为47.375±6.23%和54.27±5.33%（p = 0.002）。
PAMM常伴有眼部和全身并发疾病。OCTA结果证实，PAMM患者黄斑中心凹旁和黄斑中心凹周围SCP和DCP的灌注密度显著降低。
