Nancarrow C, Plummer J L, Ilsley A H, McLean C F, Cousins M J
Br J Anaesth. 1986 Jan;58(1):29-36. doi: 10.1093/bja/58.1.29.
Cardiovascular effects, indocyanine green clearance and the reductive metabolism of halothane were compared in 10 patients having peripheral surgery who received either general anaesthesia or general anaesthesia plus extradural blockade. Bupivacaine or saline was given extradurally 1 h before anaesthesia with nitrous oxide:oxygen (70:30) and halothane (end-tidal concentration 0.35%). Indocyanine green clearance was measured before (stage I) and after (stage II) bupivacaine or saline, during anaesthesia before surgery (stage III), and during surgery (stage IV). Reductive metabolism of halothane was assessed by measurement of exhaled 2-chloro-1,1,1-trifluoroethane. In the general anaesthesia plus extradural blockade group, arterial pressure was decreased to 58% (SD = 6) of stage I values over stages II-IV, whereas no changes were observed in the general anaesthesia group. There was no significant difference in indocyanine green clearance or the reductive metabolism of halothane, despite the occurrence of significant decreases in arterial pressure.
在10例接受外周手术的患者中，比较了全身麻醉或全身麻醉加硬膜外阻滞时的心血管效应、吲哚菁绿清除率和氟烷的还原代谢。在使用氧化亚氮：氧气（70:30）和氟烷（呼气末浓度0.35%）进行麻醉前1小时，硬膜外给予布比卡因或生理盐水。在布比卡因或生理盐水给药前（I期）和给药后（II期）、手术前麻醉期间（III期）以及手术期间（IV期）测量吲哚菁绿清除率。通过测量呼出的2-氯-1,1,1-三氟乙烷评估氟烷的还原代谢。在全身麻醉加硬膜外阻滞组中，在II-IV期动脉压降至I期值的58%（标准差=6），而全身麻醉组未观察到变化。尽管动脉压显著降低，但吲哚菁绿清除率或氟烷的还原代谢没有显著差异。
