Department of Endocrinology, Songjiang Research Institute, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Department of Orthopedics and Precision Research Center for Refractory Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
J Exp Clin Cancer Res. 2024 Oct 19;43(1):289. doi: 10.1186/s13046-024-03205-6.
Recent progress in elucidating the role of specific antidiuretic hormones in Drosophila models has provided valuable insights into the mechanisms underlying tumor-induced renal dysfunction. Xu et al. identified the mammalian neurokinin 3 receptor (TACR3), a homolog of the G protein-coupled receptor TkR99D in fruit flies, as a potential therapeutic target for alleviating renal tubular dysfunction in mice with malignant neoplasms. Here, we commented on these findings by emphasizing the structural and evolutionary significance of TACR3 and provided an in-depth analysis of cell type specific expression of TACR3 in response to renal injury and expressional dynamics during renal carcinoma progression. The implications of these findings for transforming the therapeutic approaches to renal complications associated with oncological disorders were highlighted. We also acknowledged the limitations of current experimental models in this study and emphasized the necessary clinical validation in the future. These insights could contribute to the advancement of diagnostic and therapeutic strategies for treating tumor-related renal pathologies.
最近在阐明特定抗利尿激素在果蝇模型中的作用方面的进展，为肿瘤引起的肾功能障碍的机制提供了有价值的见解。Xu 等人鉴定出哺乳动物神经激肽 3 受体（TACR3），即果蝇中 G 蛋白偶联受体 TkR99D 的同源物，作为缓解恶性肿瘤小鼠肾小管功能障碍的潜在治疗靶点。在这里，我们通过强调 TACR3 的结构和进化意义来评论这些发现，并对 TACR3 对肾损伤的细胞类型特异性表达及其在肾癌进展过程中的表达动态进行了深入分析。强调了这些发现对改变与肿瘤疾病相关的肾脏并发症的治疗方法的意义。我们还承认了本研究中当前实验模型的局限性，并强调了未来进行临床验证的必要性。这些见解有助于推进治疗与肿瘤相关的肾脏病变的诊断和治疗策略。
