Wang Y, Li R
Reproductive Medical Center, Department of Gynecology and Obstetrics, Peking University Third Hospital, Beijing 100191, China.
Zhonghua Yi Xue Za Zhi. 2024 Oct 22;104(39):3631-3635. doi: 10.3760/cma.j.cn112137-20240724-01698.
Chronic endometritis (CE) is an important factor leading to decreased endometrial receptivity, infertility, and repeated pregnancy loss; endometrial immune dysfunction, abnormal microbial flora, inflammatory status, and other factors play important roles in the occurrence and development of CE. Meanwhile, these factors are closely related to the pathophysiological mechanisms of common diseases that cause infertility, such as endometriosis, polycystic ovary syndrome, tubal diseases, and endometrial polyps. Through further development of high-quality prospective clinical research, microbiome and immunomics of CE and endometriosis,polycystic ovary syndrome and other diseases, to provide a new therapeutic idea for the treatment of refractory CE. In the course of clinical practice, the effective integration of the diagnosis and treatment principles of CE concomitant diseases in the treatment of CE is expected to provide a new choice for preventing the recurrence of CE.
慢性子宫内膜炎(CE)是导致子宫内膜容受性降低、不孕及反复流产的重要因素;子宫内膜免疫功能障碍、微生物菌群异常、炎症状态等因素在CE的发生发展中起重要作用。同时,这些因素与导致不孕的常见疾病如子宫内膜异位症、多囊卵巢综合征、输卵管疾病及子宫内膜息肉的病理生理机制密切相关。通过进一步开展高质量的前瞻性临床研究、CE及子宫内膜异位症、多囊卵巢综合征等疾病的微生物组学和免疫组学研究,为难治性CE的治疗提供新的治疗思路。在临床实践过程中,期望在CE治疗中有效整合CE合并疾病的诊治原则,为预防CE复发提供新的选择。