Benjamin L J, Manning J M
Blood. 1986 Feb;67(2):544-6.
Glyceraldehyde has been demonstrated to be an antisickling agent in vitro. In the present investigation, chromium-51 red cell studies were used to investigate the life span in vivo of sickle erythrocytes after treatment with glyceraldehyde in vitro. The mean survival (T1/2) of control cells was 5.8 +/- 1.6 days, whereas cells treated with 10 mmol/L or 20 mmol/L glyceraldehyde survived 9.0 +/- 1.4 (P less than .05) and 11.3 +/- 0.8 (P less than .002) days, respectively. The extent of modification by glyceraldehyde was 0.4 to 1.0 lysine residue per hemoglobin tetramer. These studies demonstrate not only a prolongation of the life span of sickle erythrocytes by treatment with glyceraldehyde but also the absence of any deleterious effects that would be revealed by this study.
已证明甘油醛在体外是一种抗镰状化剂。在本研究中，采用铬-51红细胞研究方法来调查体外经甘油醛处理后的镰状红细胞在体内的寿命。对照细胞的平均存活时间（T1/2）为5.8±1.6天，而用10 mmol/L或20 mmol/L甘油醛处理的细胞分别存活9.0±1.4天（P<0.05）和11.3±0.8天（P<0.002）。每个血红蛋白四聚体中甘油醛修饰的程度为0.4至1.0个赖氨酸残基。这些研究不仅证明了用甘油醛处理可延长镰状红细胞的寿命，而且还表明本研究未发现任何有害影响。
