You Jiayi, Xu Ailing, Wang Ye, Tu Guangmin, Huang Rui, Wu Shuyan
Department of Medical Microbiology, School of Basic Medical Science, Suzhou Medical College of Soochow University, Suzhou, Jiangsu Province, 215123, China.
MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Key Laboratory of Pathogen Bioscience and Anti-Infective Medicine, Suzhou Medical College of Soochow University, Suzhou, Jiangsu Province, 215123, China.
Apoptosis. 2025 Feb;30(1-2):389-400. doi: 10.1007/s10495-024-02031-7. Epub 2024 Oct 20.
As antibiotic-resistant bacteria continue to emerge frequently, bacterial infections have become a significant and pressing challenge to global public health. Innate immunity triggers the activation of host responses by sensing "non-self" components through various pattern recognition receptors (PRRs), serving as the first line of antibacterial defense. Stimulator of interferon genes (STING) is a PRR that binds with cyclic dinucleotides (CDN) to exert effects against bacteria, viruses, and cancer by inducing the production of type I interferon and inflammatory cytokines, and facilitating regulated cell death. Currently, drugs targeting the STING signaling pathway are predominantly applied in the fields of modulating host immune defense against cancer and viral infections, with relatively limited application in treating bacterial infections. Given the significant immunomodulatory functions of STING in the interaction between bacteria and hosts, this review summarizes the research progress on STING signaling pathways and their roles in bacterial infection, as well as the novel functions of STING modulators, aiming to offer insights for the development of antibacterial drugs.
随着抗生素耐药菌不断频繁出现，细菌感染已成为全球公共卫生领域一项重大且紧迫的挑战。固有免疫通过各种模式识别受体（PRR）感知“非己”成分，从而触发宿主反应的激活，构成抗菌防御的第一道防线。干扰素基因刺激因子（STING）是一种PRR，它与环二核苷酸（CDN）结合，通过诱导I型干扰素和炎性细胞因子的产生，以及促进程序性细胞死亡，来发挥抗细菌、抗病毒和抗癌作用。目前，靶向STING信号通路的药物主要应用于调节宿主对癌症和病毒感染的免疫防御领域，在治疗细菌感染方面的应用相对有限。鉴于STING在细菌与宿主相互作用中具有重要的免疫调节功能，本综述总结了STING信号通路及其在细菌感染中的作用的研究进展，以及STING调节剂的新功能，旨在为抗菌药物的开发提供思路。
