Ebong W W, Kolawole T M
Br J Rheumatol. 1986 Feb;25(1):34-9. doi: 10.1093/rheumatology/25.1.34.
Aseptic necrosis of the femoral head accounted for 75 (28.2%) of the 266 major skeletal complications seen in 207 patients with sickle-cell disease in a 66-month period. Forty-five (60%) of the 75 patients were males. The onset of symptoms occurred between the ages of 10 and 29 years in 60 (80.0%) of the patients, and the mean age at onset was 20.8 (range 8-54) years. There were 37 patients with sickle-cell anaemia (SS) with 46 hips affected by necrosis, and 38 patients with sickle-cell haemoglobin C with 40 affected hips. Perthes-like changes occurred in 40 hips, osteochondritis dissecans-like lesion in one hip and severe hip deformity in 45 hips. Four of the five hips with Perthes-like necrosis which were treated by rotation upper femoral osteotomy had partial reconstitution of the femoral head, and all five were symptom-free. The other hips were treated conservatively with generally poor results.
在66个月的时间里，对207例镰状细胞病患者进行观察，共出现266例严重骨骼并发症，其中股骨头无菌性坏死占75例（28.2%）。75例患者中45例（60%）为男性。60例（80.0%）患者症状出现的年龄在10至29岁之间，发病的平均年龄为20.8岁（范围8 - 54岁）。镰状细胞贫血（SS）患者37例，46个髋关节发生坏死；镰状细胞血红蛋白C患者38例，40个髋关节受累。40个髋关节出现佩特兹样改变，1个髋关节出现剥脱性骨软骨炎样病变，45个髋关节出现严重的髋关节畸形。接受股骨上段旋转截骨术治疗的5个佩特兹样坏死髋关节中有4个股骨头部分重建，所有5个均无症状。其他髋关节采用保守治疗，效果一般较差。
