Zohrevandi Behzad, Hosseinnia Marjan, Balikshahi Niloufar, Jobaneh Masoud, Leili Ehsan Kazemnezhad, Khodadadi-Hassankiadeh Naema
Guilan Road Trauma Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran.
Department of Clinical and Administrative Sciences, School of Pharmacy, Notre Dame of Maryland University, Baltimore, MD, USA.
Chin Neurosurg J. 2024 Oct 21;10(1):30. doi: 10.1186/s41016-024-00381-4.
Post-traumatic headache is a disabling secondary headache disorder often attributed to traumatic brain injury and affects millions of individuals worldwide. Few studies have been done on the treatment needs of these patients in emergency departments. The purpose was to compare the effectiveness of ketorolac intravenous versus acetaminophen intravenous in reducing headaches in patients following head trauma.
This was a semi-experimental study in which the participants were assigned two groups. In the acetaminophen intravenous group, 1 g acetaminophen and in the ketorolac intravenous group, 60 mg of this drug was injected. Statistical analysis was done with IBM SPSS statistical software version 21, and a P-value less than 0.05 was considered statistically significant.
Among samples after 6 h from the injection, the pain score in the ketorolac intravenous group was less than the acetaminophen intravenous group (P = 0.006). Also, the pain reduction rate in the ketorolac intravenous group was more than the acetaminophen intravenous group from before the injection until 2 h after it (P = 0.01) and before injection until 6 h after it (P = 0.001). The frequency of drowsiness in 2 and 6 h after drug administration in the ketorolac intravenous group was lower than the acetaminophen intravenous group, which is significant in 2 h after drug administration (P = 0.038). The verbal analog scale score comparison for two groups 2 h before medicine administration with pain control score (P = 0.03) and 6 h with pethidine use control (P = 0.003) is significant.
According to this study, ketorolac's intravenous effect on pain control is better than that of acetaminophen intravenous. With more samples, we can express the survey results more decisively in the future.
创伤后头痛是一种致残性继发性头痛疾病，常归因于创伤性脑损伤，影响着全球数百万人。关于这些患者在急诊科的治疗需求，很少有研究。目的是比较静脉注射酮咯酸与静脉注射对乙酰氨基酚在减轻头部创伤患者头痛方面的有效性。
这是一项半实验性研究，参与者被分为两组。静脉注射对乙酰氨基酚组注射1g对乙酰氨基酚，静脉注射酮咯酸组注射60mg该药物。使用IBM SPSS统计软件版本21进行统计分析，P值小于0.05被认为具有统计学意义。
注射后6小时的样本中，静脉注射酮咯酸组的疼痛评分低于静脉注射对乙酰氨基酚组（P = 0.006）。此外，从注射前到注射后2小时（P = 0.01）以及注射前到注射后6小时（P = 0.001），静脉注射酮咯酸组的疼痛减轻率高于静脉注射对乙酰氨基酚组。静脉注射酮咯酸组给药后2小时和6小时的嗜睡频率低于静脉注射对乙酰氨基酚组，给药后2小时差异有统计学意义（P = 0.038）。两组给药前2小时的言语模拟量表评分与疼痛控制评分比较（P = 0.03）以及给药后6小时与哌替啶使用控制评分比较（P = 0.003）差异有统计学意义。
根据本研究，静脉注射酮咯酸对疼痛控制的效果优于静脉注射对乙酰氨基酚。有了更多样本后，我们未来可以更果断地表达调查结果。
