Tsuchiya Kazuo, Suzuki Risa, Miyamoto Ryota, Tsunoda Tomo, Ito Taisuke, Mori Rie, Akashi Takuro, Oyama Yoshiyuki, Ikeda Masaki
Department of Respiratory Medicine, Shizuoka Saiseikai General Hospital, Japan.
Intern Med. 2025 Jun 1;64(11):1712-1715. doi: 10.2169/internalmedicine.4324-24. Epub 2024 Oct 18.
Thyroid transcription factor 1 (TTF-1) is primarily expressed in lung and thyroid cancers, but it has also been observed in other cancers. A 60-year-old woman presented with worsening dyspnea, pleural effusion, lung metastases, a right ovarian tumor, and para-aortic intra-abdominal lymph node metastasis. Biopsies from the pleural dissemination revealed TTF-1-positive adenocarcinomas. To confirm the presence of the primary organ, biopsies were performed on a para-aortic intra-abdominal lymph node that ascended from the ovaries. An adenocarcinoma positive for TTF-1 was identified, thus confirming the diagnosis of ovarian cancer. Our findings revealed that TTF-1 positivity does not always signify a lung cancer origin.
甲状腺转录因子1（TTF-1）主要表达于肺癌和甲状腺癌，但在其他癌症中也有发现。一名60岁女性出现呼吸困难加重、胸腔积液、肺转移、右侧卵巢肿瘤及腹主动脉旁腹腔淋巴结转移。胸膜播散灶活检显示TTF-1阳性腺癌。为确定原发器官，对来自卵巢的腹主动脉旁腹腔淋巴结进行活检。发现了TTF-1阳性腺癌，从而确诊为卵巢癌。我们的研究结果表明，TTF-1阳性并不总是意味着起源于肺癌。
