Yangzhou Center for Disease Control and Prevention, Yangzhou, Jiangsu, China.
Shanxi Health Commission Key Laboratory of Nervous System Disease Prevention and Treatment, Sinopharm Tongmei General Hospital, Datong, Shanxi, China.
Cancer Med. 2024 Oct;13(20):e70330. doi: 10.1002/cam4.70330.
Wood dust is a human carcinogen. However, studies examining the relationship between wood dust exposure and laryngeal cancer have yielded inconsistent findings. Therefore, we systematically reviewed relevant studies examining the relationship between wood dust exposure and laryngeal cancer development, followed by a meta-analysis.
Publications in the following databases were searched: PubMed, Medline, Embase, Cochrane Library, and China National Knowledge Infrastructure (CNKI). The Newcastle-Ottawa scale was used to evaluate the study quality. A random-effects model was used for the meta-analysis.
Eighteen case-control studies and one cohort study, involving a total of 4426 patients with laryngeal cancer and 319,129 control participants, were identified. The association between occupational/environmental exposure to wood dust and laryngeal cancer, if any, was unclear (adjusted combined OR: 1.11; 95% CI: 0.94-1.31). However, subgroup analyses according to the number of cases, geographic region, publication year, and follow-up duration revealed correlations between wood dust exposure correlated and laryngeal cancer, as follows: number of cases > 200 (OR: 1.14; 95% CI: 1.01-1.25 [n = 10]); studies conducted in the US (OR: 1.21; 95% CI: 1.07-1.37 [n = 5]); follow-up time > 5 years (OR: 1.19; 95% CI: 1.07-1.32 [n = 10]); and publication after the year 2000 (OR: 1.15; 95% CI: 1.04-1.28 [n = 8]). A high heterogeneity in the results was observed (I = 42.5%, p = 0.024). The results were stable, and no publication bias existed, according to sensitivity analysis.
This meta-analysis suggests that wood dust exposure is associated with laryngeal cancer. Additional large-scale studies are warranted to clarify the relationship between wood dust exposure and laryngeal cancer.
木尘是一种人类致癌物。然而，研究木材粉尘暴露与喉癌之间的关系得出的结果并不一致。因此，我们系统地回顾了检查木材粉尘暴露与喉癌发展之间关系的相关研究，并进行了荟萃分析。
在以下数据库中搜索出版物：PubMed、Medline、Embase、Cochrane Library 和中国国家知识基础设施（CNKI）。使用纽卡斯尔-渥太华量表来评估研究质量。使用随机效应模型进行荟萃分析。
确定了 18 项病例对照研究和 1 项队列研究，共涉及 4426 例喉癌患者和 319129 例对照参与者。职业/环境接触木尘与喉癌之间的关联尚不清楚（调整后的合并 OR：1.11；95%CI：0.94-1.31）。然而，根据病例数量、地理位置、发表年份和随访时间的亚组分析表明，木尘暴露与喉癌之间存在相关性：病例数>200（OR：1.14；95%CI：1.01-1.25[n=10]）；在美国进行的研究（OR：1.21；95%CI：1.07-1.37[n=5]）；随访时间>5 年（OR：1.19；95%CI：1.07-1.32[n=10]）；以及 2000 年后发表的研究（OR：1.15；95%CI：1.04-1.28[n=8]）。结果存在高度异质性（I=42.5%，p=0.024）。根据敏感性分析，结果是稳定的，不存在发表偏倚。
这项荟萃分析表明，木尘暴露与喉癌有关。需要进行更多的大规模研究来阐明木材粉尘暴露与喉癌之间的关系。
