The global, regional, and national disease burden of laryngeal cancer attributable to high alcohol use from 1990 to 2021: a global burden of disease study.

PURPOSE

This study utilized data from the Global Burden of Disease (GBD) 2021 database to comprehensively analyze the global burden of laryngeal cancer (LC) attributable to high alcohol use from 1990 to 2021, and projections to 2050.

METHODS

Data on death, disability adjusted of life years (DALYs), age-standardized death rate (ASDR), and age-standardized DALYs rate of LC attributable to high alcohol use were retrieved from the GBD 2021. Trend analysis used the estimated annual percentage change (EAPC). Death and DALYs were stratified according to social demographics index (SDI), age, gender, region, and countries. Auto-regressive integrated moving average (ARIMA) models provided future projections.

RESULTS

By 2021, global deaths of LC attributable to high alcohol use had slightly increased compared to 1990.The EAPCs for ASDR and age-standardized DALYs rate were - 1.48 and - 1.70, respectively. Males were high-risk populations and low-middle SDI regions was high-risk areas. The disease burden of LC attributable to high alcohol use varied considerably across the GBD regions and the countries. ARIMA model predicted results showed that the global deaths and DALYs cases would still increase from 2022 to 2050.

CONCLUSION

Between 1990 and 2021, while the overall burden of high alcohol use-related LC was gradually decreasing, marked regional and gender disparities persist. The annual number of LC deaths attributed to high alcohol use continues to rise, particularly in males and low-middle SDI regions. Highlights the need for more effective public health policies targeting high-risk regions and populations to reduce alcohol-related LC burden.