Romão Ivana Carneiro, Siqueira Sônia Maria Costa, Silva Abreu Flávia Oliveira Monteiro da, Santos Hélcio Silva Dos
Laboratório de Bioensaios Químicos-Farmacológicos e Ambiental-LabQFAm, Programa de Pós-Graduação em Ciências Naturais, Universidade Estadual do Ceará, 60.714903, Fortaleza, Ceará, Brazil.
Laboratório de polímeros naturais-Laponat, Programa de Pós-Graduação em Ciências Naturais, Universidade Estadual do Ceará, 60.714903, Fortaleza, Ceará, Brazil.
Chem Biodivers. 2025 Mar;22(3):e202401561. doi: 10.1002/cbdv.202401561. Epub 2024 Nov 13.
The investigation of new drugs is slow and costly. Drug repositioning, like with Hydralazine (HDZ), an old antihypertensive, can accelerate the process. HDZ and its hydrazonic derivatives exhibit diverse biological activities, promising for new drugs. This review explores HDZ's repositioning potential and its derivatives' applications in various biological activities. It identified 70 relevant articles through database searches. HDZ shows potential in neurology, oncology, nephrology, and gynecology, with clinical trials up to Phase III. Hydralazine-valproate, marketed in Mexico, proves effective in combination with chemotherapy. Hydrazonic derivatives offer broad applications in medicine. Studying their structure-activity relationship can enhance efficacy. This review summarizes their properties and pharmacological activities succinctly.
新药研发过程缓慢且成本高昂。药物重新定位，比如使用老牌抗高血压药物肼屈嗪（HDZ），可以加速这一进程。HDZ及其腙衍生物具有多种生物活性，有望开发出新的药物。本综述探讨了HDZ的重新定位潜力及其衍生物在各种生物活性中的应用。通过数据库检索确定了70篇相关文章。HDZ在神经学、肿瘤学、肾脏病学和妇科领域显示出潜力，临床试验已进入III期。在墨西哥上市的肼屈嗪-丙戊酸盐被证明与化疗联合使用有效。腙衍生物在医学上有广泛应用。研究它们的构效关系可以提高疗效。本综述简要总结了它们的性质和药理活性。
