Amin Mona, Nageeb Ahmed, Abuhashem Shadi, Saleh Abobakr, Awad Esraa, Raed Rana
Internal Medicine, Faculty of Medicine, Cairo University, Cairo, EGY.
Internal Medicine, Al-Quds University, Jerusalem, PSE.
Cureus. 2024 Sep 20;16(9):e69814. doi: 10.7759/cureus.69814. eCollection 2024 Sep.
Duodenal gastrointestinal stromal tumors (D-GISTs) are a rare subtype of GISTs, accounting for only 4% to 5% of all GIST cases. This case report details the presentation, diagnosis, and management of a 48-year-old female who presented with melena and anemia and was eventually diagnosed with a D-GIST. The tumor was identified through imaging studies, and histopathology performed after surgical resection revealed a submucosal neoplasm composed of spindle cells with extensive hemorrhage and necrosis. Given the tumor's rarity and its challenging presentation, which can mimic other conditions such as pancreatic masses, the case underscores the importance of considering D-GIST in differential diagnoses of duodenal or pancreatic lesions. Surgical resection remains the cornerstone of treatment, with adjuvant therapy considered in high-risk cases to prevent recurrence.
十二指肠胃肠道间质瘤（D-GISTs）是胃肠道间质瘤的一种罕见亚型，仅占所有胃肠道间质瘤病例的4%至5%。本病例报告详细介绍了一名48岁女性的临床表现、诊断和治疗过程，该女性因黑便和贫血就诊，最终被诊断为D-GIST。通过影像学检查发现肿瘤，手术切除后进行的组织病理学检查显示为一种由梭形细胞组成的黏膜下肿瘤，伴有广泛出血和坏死。鉴于该肿瘤的罕见性及其具有挑战性的表现，可能会被误诊为其他疾病，如胰腺肿块，该病例强调了在十二指肠或胰腺病变的鉴别诊断中考虑D-GIST的重要性。手术切除仍然是治疗的基石，高危病例可考虑辅助治疗以预防复发。
