Taramian Sonbol, Joukar Farahnaz, Maroufizadeh Saman, Hassanipour Soheil, Sheida Fateme, Mansour-Ghanaei Fariborz
School of Medicine Razi Hospital Guilan University of Medical Sciences Rasht Iran.
Gastrointestinal and Liver Diseases Research Center Guilan University of Medical Sciences Rasht Iran.
Obes Sci Pract. 2024 Oct 19;10(5):e70013. doi: 10.1002/osp4.70013. eCollection 2024 Oct.
There is a relationship between excess body weight and the risk of a number of infectious diseases, including urinary tract infections (UTIs). This study aimed to investigate the correlation between body mass index (BMI) and UTIs among Prospective Epidemiological Research Studies of the Iranian Adults (PERSIAN) Guilan Cohort Study (PGCS) population.
This cross-sectional study was conducted on 10,520 individuals aged 35-70 years from PGCS. The demographical data and clinical characteristics of the participants were recorded. Microscopic examination of the urine samples was performed to detect the presence of bacteria or white blood cells (WBC) as indicators of infection. UTI was defined as the presence of bacteria in the urine (Few, moderate, and many) and a value of ≥10 WBC/high power field (HPF) by light microscopy.
The prevalence of UTIs in this study was 8.8%, with a higher incidence in females compared to males (12.2% vs. 4.7%, < 0.001). Among participants, the prevalence of UTIs across different weight categories was as follows: underweight/normal weight, 7.1%; overweight, 8.1%; and obesity, 10.9%. According to the unadjusted model, subjects with obesity were at significantly higher odds for UTIs than subjects with underweight/normal BMI (OR = 1.62, 95% CI: 1.35-1.93, < 0.001). However, this association was no longer significant after adjusting for demographic and clinical variables.
The findings of this study provide evidence supporting a higher prevalence of UTIs among individuals with obesity.
超重与包括尿路感染（UTIs）在内的多种传染病风险之间存在关联。本研究旨在调查伊朗成年人前瞻性流行病学研究（PERSIAN）吉兰队列研究（PGCS）人群中体重指数（BMI）与UTIs之间的相关性。
本横断面研究对PGCS中10520名年龄在35至70岁之间的个体进行。记录参与者的人口统计学数据和临床特征。对尿液样本进行显微镜检查，以检测细菌或白细胞（WBC）的存在作为感染指标。UTI定义为尿液中存在细菌（少量、中度和大量）且光学显微镜下白细胞计数≥10个/高倍视野（HPF）。
本研究中UTIs的患病率为8.8%，女性发病率高于男性（12.2%对4.7%，<0.001）。在参与者中，不同体重类别UTIs的患病率如下：体重过轻/正常体重，7.1%；超重，8.1%；肥胖，10.9%。根据未调整模型，肥胖受试者患UTIs的几率显著高于体重过轻/正常BMI的受试者（OR = 1.62，95%CI：1.35 - 1.93，<0.001）。然而，在调整人口统计学和临床变量后，这种关联不再显著。
本研究结果提供了证据，支持肥胖个体中UTIs患病率较高。
