van der Lelie H, Monasch E, Pegels H G, von dem Borne A E
Cancer. 1986 Jan 15;57(2):226-9. doi: 10.1002/1097-0142(19860115)57:2<226::aid-cncr2820570207>3.0.co;2-i.
In 12 of 18 patients with multiple myeloma refractory to treatment with the combination of vincristine, melphalan, cyclophosphamide, and prednisone, favorable results were obtained by replacing vincristine in this combination with vindesine. Although only three patients showed marked reductions (greater than 50%) of myeloma protein, this treatment, which was well tolerated, was also clearly beneficial to the other responding patients, thus postponing the need for more toxic treatment programs.
在18例对长春新碱、美法仑、环磷酰胺和泼尼松联合治疗难治的多发性骨髓瘤患者中，有12例通过用长春地辛替代该联合方案中的长春新碱取得了良好疗效。虽然只有3例患者的骨髓瘤蛋白显著降低（超过50%），但这种耐受性良好的治疗方法对其他有反应的患者也明显有益，从而推迟了采用毒性更强的治疗方案的必要性。
