Olsson C G
Scand J Clin Lab Invest. 1979 Nov;39(7):677-84. doi: 10.3109/00365517909108874.
The [125I]fibrinogen uptake test was modified to give a quick result, and improve sensitivity and specificity in the diagnosis of deep venous thrombosis (DVT). At least 800 counts were recorded at each measuring point. The leg veins were emptied more effectively. Thus the proximal thigh could be evaluated and the influence of varicose veins reduced. The feet and the leg points were measured in a zig-zag order (from side to side) to avoid systematic errors in early diagnosis. The modified test detected 62% of the thrombi 1 h after injection, 82% after 1 day and 95% after 2 days. The method still lacks in specificity; this is unavoidable since fibrin accumulates in various other conditions than DVT. The combination of high sensitivity and low specificity makes the modified test reliable as a screening procedure, but not as an independent method.
对[125I]纤维蛋白原摄取试验进行了改进，以获得快速结果，并提高诊断深静脉血栓形成（DVT）的敏感性和特异性。每个测量点记录至少800次计数。腿部静脉排空更有效。因此，可以评估大腿近端，并减少静脉曲张的影响。以之字形顺序（从一侧到另一侧）测量足部和腿部各点，以避免早期诊断中的系统误差。改良试验在注射后1小时检测到62%的血栓，1天后检测到82%，2天后检测到95%。该方法仍缺乏特异性；这是不可避免的，因为除了DVT之外，纤维蛋白还会在各种其他情况下积聚。高敏感性和低特异性的结合使得改良试验作为一种筛查程序是可靠的，但不能作为一种独立的方法。
