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益生菌酸奶对儿科患者抗生素相关性腹泻的影响;随机对照试验。

Effect of probiotic yogurt on antibiotic-associated diarrhea among pediatric patients; randomized controlled trial.

作者信息

Shyoran Rajesh, Kaur Amanjot, Bharat Pareek, Pathania Rimple

机构信息

Department of Child Health Nursing, SPHE College of Nursing, Gharuan, Mohali, Punjab, India.

RN, M.Sc. Child Health Nursing, Assistant Professor, SPHE College of Nursing, Gharuan, Mohali, Punjab, India.

出版信息

J Educ Health Promot. 2024 Aug 29;13:317. doi: 10.4103/jehp.jehp_1497_23. eCollection 2024.

DOI:10.4103/jehp.jehp_1497_23
PMID:39429834
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11488776/
Abstract

BACKGROUND

Diarrhea is a common unfavorable consequence of antibiotics. Probiotic yogurt is equally effective as probiotic capsules, so it may provide a simple and cost-effective means of preventing antibiotic-associated diarrhea (AAD). The study aimed to evaluate the effect of probiotic yogurt on AAD among pediatric patients.

MATERIALS AND METHODS

The randomized controlled trial design was adopted in this investigation, with a post-test-only control group. Data were obtained from 244 pediatric patients on antibiotics who were admitted to the hospital and included in the trial via full enumeration sampling. Selected subjects were randomly assigned to experimental (n = 122) or control (n = 122) groups. The experimental group received probiotic yogurt for five days, whereas the control group received standard care. The incidence and severity of diarrhea on the fifth day of the intervention were used to determine the study's results. The trial was registered with the Clinical Trials Registry - India (CTRI). Consolidated Standards of Reporting Trials (CONSORT) were followed. Descriptive and inferential statistics were used for data analysis. Statistical software was used for descriptive and inferential analysis.

RESULTS

AAD occurred in 13.90% and 36.88% of individuals in the experimental and control groups, respectively ( Further, yogurt intervention was found to be effective in terms of increasing the consistency of the stool (p. 001*), decreasing the duration and onset of diarrhea ( ≤ .001 reducing the frequency and amount of loose stool ( ≤ .001*), reducing the urgency of defecation ( ≤ .001*), the presence of abdominal discomfort ( ≤ .001 and dehydration ( ≤ .001

CONCLUSION

In hospitals, antibiotics are commonly prescribed, and the most common side effect of medications is diarrhea. Probiotic yogurt guards against this side effect of antibiotics. Nurse practitioners need to understand the value of probiotic yogurt as a preventive measure that could save children's lives.

摘要

背景

腹泻是抗生素常见的不良后果。益生菌酸奶与益生菌胶囊效果相同,因此它可能提供一种简单且经济有效的预防抗生素相关性腹泻(AAD)的方法。本研究旨在评估益生菌酸奶对儿科患者AAD的影响。

材料与方法

本调查采用随机对照试验设计,设仅后测对照组。数据来自244名因使用抗生素而住院的儿科患者,通过完全枚举抽样纳入试验。选定的受试者被随机分为实验组(n = 122)或对照组(n = 122)。实验组接受益生菌酸奶治疗五天,而对照组接受标准护理。干预第五天腹泻的发生率和严重程度用于确定研究结果。该试验已在印度临床试验注册中心(CTRI)注册。遵循了报告试验的统一标准(CONSORT)。采用描述性和推断性统计进行数据分析。使用统计软件进行描述性和推断性分析。

结果

实验组和对照组分别有13.90%和36.88%的个体发生AAD(此外,发现酸奶干预在增加大便稠度方面有效(p. 001*),减少腹泻持续时间和发作时间(≤.001*),减少稀便频率和量(≤.001*),降低排便紧迫感(≤.00*),减轻腹部不适(≤.001*)和脱水(≤.001*)。

结论

在医院中,抗生素常被处方使用,而药物最常见的副作用是腹泻。益生菌酸奶可预防抗生素的这种副作用。执业护士需要了解益生菌酸奶作为一种可挽救儿童生命的预防措施的价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f70b/11488776/1266b5df7c22/JEHP-13-317-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f70b/11488776/1266b5df7c22/JEHP-13-317-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f70b/11488776/1266b5df7c22/JEHP-13-317-g001.jpg

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BMJ Open. 2021 Aug 12;11(8):e043054. doi: 10.1136/bmjopen-2020-043054.
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Probiotics for the Prevention of Antibiotic-associated Diarrhea in Adults: A Meta-Analysis of Randomized Placebo-Controlled Trials.
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A retrospective study of probiotics for the treatment of children with antibiotic-associated diarrhea.一项关于益生菌治疗儿童抗生素相关性腹泻的回顾性研究。
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