转基因小鼠在白内障分子发病机制中的应用。
Application of transgenic mice to the molecular pathogenesis of cataract.
作者信息
Zhang Yue, Chen Xiao-Ya, Hu Yu-Zhu, Zhang Xiao, Zheng Shun-Fei, Hu Shan-Shan
机构信息
Mudanjiang Medical University, Mudanjiang 157011, Heilongjiang Province, China.
Department of Ophthalmology, Hongqi Hospital of Mudanjiang Medical University, Mudanjiang 157011, Heilongjiang Province, China.
出版信息
Int J Ophthalmol. 2024 Oct 18;17(10):1929-1948. doi: 10.18240/ijo.2024.10.21. eCollection 2024.
One of the most prevalent disorders that cause blindness worldwide is cataract, and its essence is the visual disorder caused by the opacity of the lens. The significant degree of variation in cataracts and the fact that a variety of factors can impact a patient's lens transparency make it especially crucial to investigate the pathogenesis of cataracts at the molecular level. It has been found that more than 60 genes are linked to the formation of cataracts, and the construction of a transgenic mouse model of cataract similar to the selection of human lens clouding due to a variety of causes has become an important means of studying the pathogenesis of cataract. Therefore, the research on the application of transgenic mice to the molecular pathogenesis of cataracts will be the main topic of this review of the literature.
白内障是全球范围内导致失明的最常见疾病之一，其实质是由晶状体混浊引起的视觉障碍。白内障的显著程度差异以及多种因素会影响患者晶状体透明度这一事实，使得在分子水平上研究白内障的发病机制尤为关键。现已发现60多个基因与白内障的形成有关，构建类似于人类因多种原因导致晶状体混浊的白内障转基因小鼠模型，已成为研究白内障发病机制的重要手段。因此，转基因小鼠在白内障分子发病机制中的应用研究将是本文献综述的主要主题。
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