乳腺癌中与CD44和CD63表达相关的临床病理特征。
Clinicopathological features associated with CD44 and CD63 expression in breast cancer.
作者信息
Castaneda Carlos A, Castillo Miluska, Sanchez Joselyn, Bernabe Luis, Tello Katherin, Suarez Nancy, Alatrista Raul, Quiroz-Gil Ximena, Granda-Oblitas Alexandra, Enciso Javier, Enciso Nathaly, Gomez Henry L
机构信息
Faculty of Health Sciences, Universidad Cientifica del Sur, Lima 15067, Peru.
Department of Medical Oncology, Instituto Nacional de Enfermedades Neoplasicas, Lima 15038, Peru.
出版信息
Ecancermedicalscience. 2024 Sep 26;18:1779. doi: 10.3332/ecancer.2024.1779. eCollection 2024.
BACKGROUND
CD44 is a cell-surface transmembrane glycoprotein that participates in the regulation of many cellular processes, including cell division, adhesion, migration and stem-like characteristics. CD63 is involved in the exocytosis process.
OBJECTIVE
To evaluate the relationship between CD44 and CD63 expression and clinicopathological features, including tumor-infiltrating lymphocytes (TILs), phosphoinositide 3-kinase (PIK3CA) mutation and survival.
METHODOLOGY
CD44 and CD63 were stained in samples from 101 breast cancer cases from Peruvian women.
RESULTS
Median age was 52 years, most were most were grade-3 (68%), estrogen receptor (ER)+ (64%) and stage II-III (92%). Median ki67 was 30%, median stromal TIL was 30% and mutation was found in 49%. Longer survival was associated with earlier stages ( = 0.016), lower ki67 ( = 0.023), ER+ ( = 0.034), luminal phenotype ( = 0.029) and recurrence ( < 0.001). CD44 was classified as high cell density staining in 57% and high intensity in 55%. High CD44 density was associated with younger age ( = 0.043), triple-negative phenotype ( = 0.035) and shorter survival ( = 0.005). High CD44 expression was associated with short survival ( = 0.005). High CD63 cell density was found in 56% of cases and was associated with ER-positive ( = 0.045), low TIL levels ( = 0.007), Luminal-A ( = 0.015) and low CD44 intensity ( = 0.032).
CONCLUSION
CD44 expression was associated with aggressive features and low CD63 density staining.
背景
CD44是一种细胞表面跨膜糖蛋白，参与多种细胞过程的调节，包括细胞分裂、黏附、迁移和干细胞样特性。CD63参与胞吐过程。
目的
评估CD44和CD63表达与临床病理特征之间的关系，包括肿瘤浸润淋巴细胞（TILs）、磷酸肌醇3激酶（PIK3CA）突变和生存率。
方法
对101例秘鲁女性乳腺癌病例的样本进行CD44和CD63染色。
结果
中位年龄为52岁，大多数为3级（68%）、雌激素受体（ER）阳性（64%）和II-III期（92%）。中位Ki67为30%，中位基质TIL为30%，49%发现有突变。生存期较长与早期阶段（P = 0.016）、较低的Ki67（P = 0.023）、ER阳性（P = 0.034）、管腔表型（P = 0.029）和无复发（P < 0.001）相关。57%的CD44被分类为高细胞密度染色，55%为高强度。高CD44密度与较年轻的年龄（P = 0.043）、三阴性表型（P = 0.035）和较短的生存期（P = 0.005）相关。高CD44表达与较短的生存期（P = 0.005）相关。56%的病例发现高CD63细胞密度，且与ER阳性（P = 0.045）、低TIL水平（P = 0.007）、管腔A型（P = 0.015）和低CD44强度（P = 0.032）相关。
结论
CD44表达与侵袭性特征和低CD63密度染色相关。
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