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Extremely Long-Lasting B-cell Depletion and BAFFling Effects Following Obinutuzumab-Based Regimen in Lupus Nephritis.

作者信息

Roccatello Dario, Sciascia Savino, De Simone Emanuele, Schindler Thomas, Martins Elsa, Mao Huiyan Ashley, Rossi Daniela, Fenoglio Roberta

机构信息

University Center of Excellence on Nephrological, Rheumatological and Rare Diseases (ERK-net, ERN-Reconnet and RITA-ERN Member) Including Nephrology and Dialysis Unit and Center of Immuno-Rheumatology and Rare Diseases (CMID), Coordinating Center of the Interregional Network for Rare Diseases of Piedmont and Aosta Valley (North-West Italy), San Giovanni Bosco Hub Hospital, ASL Città di Torino and Department of Clinical and Biological Sciences of the University of Turin, Turin, Italy.

F. Hoffmann-La Roche AG, Basel, Switzerland.

出版信息

Kidney Int Rep. 2024 Aug 10;9(10):3079-3080. doi: 10.1016/j.ekir.2024.08.008. eCollection 2024 Oct.

DOI:10.1016/j.ekir.2024.08.008
PMID:39430193
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11489493/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8456/11489493/a7ead4b7df7c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8456/11489493/a7ead4b7df7c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8456/11489493/a7ead4b7df7c/gr1.jpg

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本文引用的文献

1
B-cell depletion with obinutuzumab for the treatment of proliferative lupus nephritis: a randomised, double-blind, placebo-controlled trial.奥滨尤妥珠单抗治疗增生性狼疮肾炎的 B 细胞耗竭：一项随机、双盲、安慰剂对照试验。
Ann Rheum Dis. 2022 Jan;81(1):100-107. doi: 10.1136/annrheumdis-2021-220920. Epub 2021 Oct 6.
2
Elevated serum BAFF levels are associated with rising anti-double-stranded DNA antibody levels and disease flare following B cell depletion therapy in systemic lupus erythematosus.在系统性红斑狼疮中，血清BAFF水平升高与抗双链DNA抗体水平升高以及B细胞清除疗法后的疾病复发相关。
Arthritis Rheum. 2013 Oct;65(10):2672-9. doi: 10.1002/art.38074.
3
Resolve, revise, and relax: the 3 Rs of B cell repertoire adjustment.
解决、修正、放松：B 细胞受体库调整的 3R 原则。
Immunol Lett. 2012 Mar 30;143(1):2-8. doi: 10.1016/j.imlet.2012.01.014. Epub 2012 Feb 6.
4
Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity.通过工程改造新型 II 型抗 CD20 抗体，增强直接和免疫效应细胞介导的 B 细胞细胞毒性，提高 CD20 抗体治疗的疗效。
Blood. 2010 Jun 3;115(22):4393-402. doi: 10.1182/blood-2009-06-225979. Epub 2010 Mar 1.