在TC 199培养条件下“治愈”的巨幼细胞贫血病例中的着丝粒扩展。
Centromere spreading in a case of megaloblastic anemia "cured" under TC 199 culture conditions.
作者信息
Bamezai R, Shiraishi Y, Taguchi H
出版信息
Cancer Genet Cytogenet. 1986 Feb 15;20(3-4):341-3. doi: 10.1016/0165-4608(86)90093-2.
PMID:3943072
Abstract
The present study discusses the possible reasons of appearance and disappearance of centromere spreading in chromosomes obtained from bone marrow cultures in RPMI 1640 and TC 199 media, respectively, in a case of megaloblastic anemia. This prevention or curing effect of centromeric region is suggested to have occurred due to exogenous thymidine present in TC 199 medium, probably reflecting the failure of proper DNA synthesis.
摘要
本研究探讨了在巨幼细胞贫血病例中，分别在RPMI 1640培养基和TC 199培养基中从骨髓培养物获得的染色体上着丝粒扩散出现和消失的可能原因。着丝粒区域的这种预防或治愈作用被认为是由于TC 199培养基中存在外源性胸苷而发生的，这可能反映了正常DNA合成的失败。
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