海德堡遗传筛选 40 年：改变发育和细胞生物学的历程。
40 years since the Heidelberg genetic screen that revolutionized developmental and cell biology.
机构信息
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
出版信息
Development. 2024 Nov 1;151(21). doi: 10.1242/dev.204433. Epub 2024 Oct 21.
Abstract
Our current understanding of the molecular basis of embryonic development and the shared machinery underlying this remarkable process has its roots in three papers published 40 years ago, which summarize the results of the Nobel Prize-winning 'Heidelberg screen'. The genesis of these experiments that empowered us and the stories behind the experiments are worth revisiting.
摘要
我们目前对于胚胎发育的分子基础以及这一非凡过程所共有的机制的理解，可以追溯到 40 年前发表的三篇论文，它们总结了诺贝尔奖获奖的“海德堡筛选”的结果。这些实验的起源以及实验背后的故事值得我们重新审视。
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