Alzamanan Fatema, Ding Yuan, Harroud Adil
The Neuro (Montreal Neurological Institute-Hospital), Montréal, Quebec, Canada.
Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada.
Ann Neurol. 2024 Oct 21;97(1):90-4. doi: 10.1002/ana.27112.
Obesity is implicated in the development of multiple sclerosis (MS), but its effect on disability is less well-established. This study examined the effects of various obesity measures on MS severity in 12,584 MS cases, using Mendelian randomization to mitigate confounding. Results showed a significant association between higher genetically-determined body mass index (N = 806,834) and increased MS severity (P = 0.02). This finding was supported by additional measures of general obesity but not adiposity distribution. The convergence of this genetic evidence with prior observational studies strengthens the association between obesity and adverse long-term disability in MS, suggesting weight management as a potential therapeutic strategy. ANN NEUROL 2024.
肥胖与多发性硬化症（MS）的发生有关，但其对残疾的影响尚不明确。本研究使用孟德尔随机化方法以减轻混杂因素的影响，在12584例MS患者中考察了各种肥胖指标对MS严重程度的影响。结果显示，遗传决定的较高体重指数（N = 806834）与MS严重程度增加之间存在显著关联（P = 0.02）。这一发现得到了一般肥胖的其他指标的支持，但未得到脂肪分布指标的支持。这一遗传证据与先前观察性研究的结果一致，强化了肥胖与MS不良长期残疾之间的关联，提示体重管理可能是一种潜在的治疗策略。《神经病学年鉴》2024年。
