Durdu Habibe, Sahin Ulku Kezban, Karagoz Arzu Demircioglu, Kulakli Fazil
Department of Therapy and Rehabilitation, Giresun University, Vocational School of Health Services, Giresun, Turkey.
Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey.
J Eval Clin Pract. 2025 Aug;31(5):e14197. doi: 10.1111/jep.14197. Epub 2024 Oct 21.
Exercise capacity declines with age. However, the effect of common geriatric symptoms, that are related to physical performance, on exercise capacity is unclear.
The study aimed to determine the impacts of sarcopenia, frailty, balance, and depression on both overall and abnormal exercise capacity.
One hundred and nineteen community-dwelling older adults over 65 years of age were included in the cross-sectional study. Sarcopenia and frailty status were determined according to the "European Working Group on Sarcopenia in Older People2" and "Fried frailty criteria", respectively. Exercise capacity, balance and depression were assessed with the 6-min walk test (6MWT), the Timed Up and Go Test (TUG) and the Geriatric Depression Scale (GDS), respectively.
Of the participants, 5% were sarcopenic, 32.8% were frail, and 29.4% had abnormal exercise capacity (6MWT < 82% pred). According to multivariate linear regression analysis, the model consisting of sarcopenia, frailty, TUG and GDS was explained 53% of the variation in 6MWT (R = 0.73, R = 0.53, p < 0.001), and all variables except GDS were independent predictors of exercise capacity (p < 0.05). Sarcopenia was the strongest predictor of 6MWT (β =-79.76, p = 0.011). The model including sarcopenia, TUG, frailty, and GDS provided 29% prediction of abnormal exercise capacity (Nagelkerke R = 29.7, p < 0.001), while TUG was the sole significant predictor in the model (Odd Ratio:1.32, p < 0.002), according to logistic regression analysis.
This study indicates that changes in exercise capacity are more influenced by the presence of sarcopenia, and that poor TUG performance is the greatest risk factor for the impaired exercise capacity.
运动能力随年龄下降。然而，与身体机能相关的常见老年症状对运动能力的影响尚不清楚。
本研究旨在确定肌肉减少症、衰弱、平衡能力和抑郁对总体运动能力和异常运动能力的影响。
119名65岁以上的社区居住老年人纳入了这项横断面研究。分别根据“欧洲老年人肌肉减少症工作组2”和“弗里德衰弱标准”确定肌肉减少症和衰弱状态。运动能力、平衡能力和抑郁分别通过6分钟步行试验（6MWT）、定时起立行走试验（TUG）和老年抑郁量表（GDS）进行评估。
参与者中，5%患有肌肉减少症，32.8%衰弱，29.4%运动能力异常（6MWT＜预测值的82%）。根据多元线性回归分析，由肌肉减少症、衰弱、TUG和GDS组成的模型解释了6MWT中53%的变异（R = 0.73，R² = 0.53，p＜0.001），除GDS外的所有变量都是运动能力的独立预测因素（p＜0.05）。肌肉减少症是6MWT最强的预测因素（β = -79.76，p = 0.011）。根据逻辑回归分析，包括肌肉减少症、TUG、衰弱和GDS的模型对异常运动能力的预测率为29%（Nagelkerke R² = 29.7，p＜0.001），而TUG是该模型中唯一显著的预测因素（比值比：1.32，p＜0.002）。
本研究表明，运动能力的变化受肌肉减少症的影响更大，且TUG表现不佳是运动能力受损的最大风险因素。
