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林奇综合征患者妇科恶性肿瘤的筛查和预防现状或缺乏现状。

The Current State-or Lack Thereof-of Screening and Prevention for Gynecologic Malignancies for Patients With Lynch Syndrome.

机构信息

Department of Obstetrics, Gynecology and Reproductive Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.

出版信息

Clin Obstet Gynecol. 2024 Dec 1;67(4):687-695. doi: 10.1097/GRF.0000000000000892. Epub 2024 Oct 18.

Abstract

Lynch syndrome (LS) is an autosomal dominant genetic disorder that results in an increased risk of ovarian and endometrial cancers. The aim of this paper was to explore the management of this risk through screening and prevention. Published materials and evidence were explored and summarized. This paper demonstrated that while there has been increased awareness and advances in the identification and diagnosis of patients with LS, recommendations for screening and prevention remain less evidence-based. In decisions of management of patients with LS, a shared decision-making model should be used considering individual patient goals.

摘要

林奇综合征(LS)是一种常染色体显性遗传疾病,会增加卵巢癌和子宫内膜癌的风险。本文旨在探讨通过筛查和预防来管理这种风险。本文对已发表的材料和证据进行了探讨和总结。研究表明,虽然人们对 LS 患者的识别和诊断的认识有所提高,也取得了一定的进展,但有关筛查和预防的建议仍然缺乏足够的证据支持。在 LS 患者的管理决策中,应考虑到个体患者的目标,采用共同决策模式。

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