Gutierrez-Bayona Natalia E, Petersen Camryn, Hashmi Raabia H, Buonanno Manuela, Shuryak Igor, Ponnaiya Brian, Kleiman Norman J, Brenner David J, Welch David
Center for Radiological Research, Columbia University Irving Medical Center, New York City, New York, USA.
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University Irving Medical Center, New York City, New York, USA.
Photochem Photobiol. 2025 May-Jun;101(3):673-682. doi: 10.1111/php.14035. Epub 2024 Oct 21.
Guidance on maximal limits for ultraviolet (UV) exposure has been developed by national and international organizations to protect against adverse effects on human skin and eyes. These guidelines consider the risk of both acute effects (i.e., erythema and photokeratitis) and delayed effects (e.g., skin and ocular cancers) when determining exposure limits, and specify the dose a person can safely receive during an 8-h period without harmful effects. The determination of these exposure limits relies on the action spectra of photobiological responses triggered by UV radiation that quantify the effectiveness of each wavelength at eliciting each of these effects. With growing interest in using far-UVC (200-235 nm) radiation to control the spread of airborne pathogens, recent arguments have emerged about revisiting exposure limits for UV wavelengths. However, the standard erythema action spectrum, which provides some of the quantitative basis for these limits, has not been extended below 240 nm. This study assists to expand the erythema action spectrum to far-UVC wavelengths using a hairless albino mice model. We estimate that inducing acute effects on mouse skin with 222 nm radiation requires a dose of 1162 mJ/cm, well above the current ACGIH skin exposure limit of 480 mJ/cm.
国家和国际组织已制定了紫外线（UV）暴露最大限值指南，以防止对人体皮肤和眼睛产生不良影响。这些指南在确定暴露限值时考虑了急性效应（即红斑和光角膜炎）和延迟效应（如皮肤癌和眼癌）的风险，并规定了一个人在8小时内可安全接受而无有害影响的剂量。这些暴露限值的确定依赖于紫外线辐射引发的光生物学反应的作用光谱，该光谱量化了每个波长引发这些效应的有效性。随着人们对使用远紫外线C（200 - 235纳米）辐射控制空气传播病原体传播的兴趣日益浓厚，最近出现了关于重新审视紫外线波长暴露限值的争论。然而，为这些限值提供部分定量依据的标准红斑作用光谱尚未扩展到240纳米以下。本研究利用无毛白化小鼠模型，协助将红斑作用光谱扩展到远紫外线C波长。我们估计，用222纳米辐射在小鼠皮肤上诱发急性效应所需剂量为1162毫焦/平方厘米，远高于美国政府工业卫生学家会议（ACGIH）目前480毫焦/平方厘米的皮肤暴露限值。
