Gómez-Tenés Guillermo, Gimeno-Fonquernie Pol, Misturini Alechania, Chinchilla-Garzón Clara, Carratalá Víctor, Cisneros Larisha, Martí-Gastaldo Carlos
Functional Inorganic Materials Team, Instituto de Ciencia Molecular (ICMol), Universitat de València, Paterna 46980, Spain.
Chem Commun (Camb). 2024 Nov 5;60(89):12977-12985. doi: 10.1039/d4cc03456b.
Reticular chemistry has in the post-synthetic modification (PSM) of frameworks one of the most versatile tools to adapt the systems' physicochemical properties to the specific requirements which are imposed by their application in different contexts. We can safely say that PSM methodologies in all their variants are currently one of the main resources that reticular chemists turn to when they need to diversify a framework compositionally. Practically all these modifications require the integration of functional groups appended to the organic linkers in the framework, either by direct synthesis or by post-synthetic exchange. The reactivity of these tags allows, at a subsequent stage, covalent modification of the framework under conditions that ideally respect its structural integrity. In this perspective article we introduce the use of tetrazine-based linkers as intrinsically tagged alternatives to integrate PSM with click chemistry reactivity. This strategy is ideally suited to molecular frameworks, as it combines very mild modification conditions with direct control over the organisation of built-in appendices and the acknowledged potential of click chemistry to build framework libraries.
网状化学在框架的合成后修饰（PSM）中是一种极为通用的工具，可使体系的物理化学性质适应于因其在不同情境中的应用而产生的特定要求。我们可以确切地说，目前，各种变体的PSM方法是网状化学家在需要从组成上使框架多样化时所依赖的主要资源之一。实际上，所有这些修饰都需要通过直接合成或合成后交换，将连接到框架中有机连接体上的官能团整合进去。这些标签的反应活性使得在后续阶段能够在理想情况下尊重其结构完整性的条件下对框架进行共价修饰。在这篇观点文章中，我们介绍使用基于四嗪的连接体作为具有内在标签的替代物，将PSM与点击化学反应性相结合。这种策略非常适合分子框架，因为它将非常温和的修饰条件与对内置附件组织的直接控制以及点击化学在构建框架库方面公认的潜力结合在一起。
